Long-term depression in horizontal slices of the rat lateral amygdala

Synapse
Tobias KaschelD Albrecht

Abstract

Long-term depression (LTD) is an enduring decrease in synaptic efficacy and is thought to underlie memory. In contrast to investigations of plasticity mechanisms in the amygdala in rat coronal slices, this study was done in horizontal slices. Field excitatory postsynaptic potentials (fEPSPs) and EPSPs, respectively, were recorded extracellularly and intracellularly from the lateral nucleus of the amygdala (LA). We show that low-frequency stimulation (LFS) induces LTD in the LA, when stimulation electrodes were located in the LA. No significant differences were found between females and males. In dependence of strain variations, a reduction of GABAergic inhibition either reduced the magnitude of LTD or was a prerequisite for the induction of extracellularly recorded LA-LTD. Theta pulse stimulation (TPS) of afferents within the LA caused a weaker LTD than LFS. Theta burst stimulation (TBS) given 20 min after the end of LFS reversed LTD, whereas high-frequency stimulation (HFS) resulted in long-term potentiation (LTP) that was significantly stronger than that obtained in naive slices. Therefore, primed induction of LTD facilitates high-frequency-induced LTP in the rat lateral amygdala. NMDARs as well as group II mGluRs were involv...Continue Reading

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Citations

Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Manja Schubert, Doris Albrecht
Oct 6, 2005·Learning & Memory·Manja SchubertDoris Albrecht
Aug 31, 2011·Journal of Neuroscience Methods·C KulischD Albrecht
Aug 27, 2013·Behavioural Processes·Lorenzo Díaz-MataixValérie Doyère
Feb 22, 2014·Behavioural Brain Research·Joanna Danielewicz, Grzegorz Hess
Nov 5, 2016·Neurobiology of Learning and Memory·Christine GebhardtDoris Albrecht
May 10, 2008·Nature Reviews. Neuroscience·Paulo S Pinheiro, Christophe Mulle
Nov 21, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manja SchubertDoris Albrecht

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