Long-term depression in the sensorimotor cortex induced by repeated delivery of 10 Hz trains in vivo

Neuroscience
Christine M WerkC Andrew Chapman

Abstract

Memory consolidation in the neocortex is thought to be mediated in part by bi-directional modifications of synaptic strength. The sensorimotor cortex shows marked spontaneous activity near 10 Hz during both waking and sleep in the form of electroencephalographic spindle waves, and is also sensitive to electrical activation of inputs at 10 Hz. Induction of long-term synaptic depression in corpus callosum inputs to layer V of the sensorimotor cortex of the awake, adult rat requires repeated low-frequency stimulation over many days. To determine if 10 Hz stimulation may facilitate the induction of long-term depression, we compared the amounts of long-term depression induced by conventional 1 Hz trains, repeated delivery of 450 pairs of stimulation pulses using a 100 ms interpulse interval, and 45 short, 2 s, 10 Hz trains. Each pattern was delivered daily for 10 days and was matched for total duration and number of pulses. Changes in synaptic responses were assessed by monitoring field potentials evoked by stimulation of the corpus callosum. A facilitation of synaptic responses in layer V was observed during delivery of both paired-pulse trains and 10 Hz trains. There was no significant difference in long-term depression induced by...Continue Reading

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Citations

Jan 22, 2011·Journal of Neural Engineering·James M Rebesco, Lee E Miller
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhong-Wu LiuXiao-Bing Gao
May 24, 2012·Neural Plasticity·Giulio Tononi, Chiara Cirelli
Oct 1, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Mina SadighiAli Pshapour
Mar 15, 2016·Current Biology : CB·Hiroyuki Miyawaki, Kamran Diba
May 1, 2008·The European Journal of Neuroscience·Til Ole BergmannHartwig Roman Siebner
Apr 14, 2010·The European Journal of Neuroscience·Tomas RosJohn C Rothwell
Oct 17, 2008·Journal of Neurophysiology·Fadi N Karameh, Steve G Massaquoi
Jun 14, 2016·Neural Plasticity·Christoph LindemannIleana L Hanganu-Opatz

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