Long-Term Depression of Intrinsic Excitability Accompanied by Synaptic Depression in Cerebellar Purkinje Cells

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Hyun Geun ShimSang Jeong Kim

Abstract

Long-term depression (LTD) at the parallel fiber (PF)-to-cerebellar Purkinje cell (PC) synapse is implicated in the output of PCs, the sole output of the cerebellar cortex. In addition to synaptic plasticity, intrinsic excitability is also one of the components that determines PC output. Although long-term potentiation of intrinsic excitability (LTP-IE) has been suggested, it has yet to be investigated how PF-PC LTD modifies intrinsic excitability of PCs. Here, we show that pairing of the PF and climbing fiber (CF) for PF-PC LTD induction evokes LTD-IE in cerebellar PCs from male C57BL/6 mice. Interestingly, this intrinsic plasticity showed different kinetics from synaptic plasticity, but both forms of plasticity share Ca2+ signaling and protein kinase C pathway as their underlying mechanism. Although small-conductance Ca2+-activated K+ channels play important roles in LTP-IE, no direct implication has been found. After PF-PC LTD induction, neither the temporal summation of dendritic EPSP nor the power of spike frequency adaptation is changed, indicating that cerebellar LTD executes the information processing in a quantitative way without quality changes of synaptic integration and generation of output signals. Our results sugg...Continue Reading

Citations

Feb 13, 2018·Human Molecular Genetics·Ravi ChopraVikram G Shakkottai
Jan 5, 2020·The Cerebellum·Chi-Ying LinUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 6, 2020·The FEBS Journal·Gen OhtsukiAkitoshi Ozaki
Aug 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Desheng WangBernard G Schreurs
May 20, 2019·Pflügers Archiv : European journal of physiology·Dong Cheol Jang, Sang Jeong Kim
Feb 10, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Hyung-Ji KimJae-Hong Lee
Sep 21, 2019·Neurobiology of Learning and Memory·Dominique Debanne, Michaël Russier

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