Long-term developmental outcome in patients with West syndrome after epilepsy surgery

Brain & Development
Yoshiko IwataniKeiichi Ozono

Abstract

It has been hypothesized that early seizure control may prevent children with intractable epileptic spasms (ES) from developmental regression and may contribute to better developmental outcome. The effectiveness of surgery for ES has been reported. We investigated long-term post-operative outcomes of seizure control and development in patients with symptomatic West syndrome (S-WS) who underwent epilepsy surgery. Six children who underwent surgical intervention for intractable ES were retrospectively investigated. Cortical malformations were observed on pre-operative MRI in all patients, with hemispheric or multilobar involvement in four children and focal lesions in two. Following surgery, we measured motor function, developmental age (DA), language skills, and sociopsychological function for up to 7years (mean, 4.9years). Post-operative seizure outcome was Engel Class I (n=4) or III (n=2). Motor function and DA was increased following surgery in six and five patients, respectively. Two patients started to speak in sentences following focal resection. Autistic features were noted in four of the five examined patients post-operatively. None of the patients showed developmental regression following surgery. Epilepsy surgery for S...Continue Reading

References

Jan 1, 1981·Folia Psychiatrica Et Neurologica Japonica·Y Yamatogi, S Ohtahara
Jul 1, 1993·Epilepsia·H T ChuganiW J Peacock
Apr 1, 1997·Pediatric Neurology·U KramerM A Mikati
Nov 18, 1998·Annals of Neurology·E WyllieP Ruggieri
Nov 27, 1999·Developmental Neuroscience·R CaplanM Sigmann
Nov 10, 2001·Brain & Development·E AsanoH T Chugani
Jan 10, 2002·Brain and Language·S CurtissG W Mathern
Feb 5, 2003·Brain : a Journal of Neurology·A M DevlinB G R Neville
Mar 1, 2006·Brain & Development·Hoon-Chul KangTae-Sung Ko
Jun 20, 2006·Developmental Medicine and Child Neurology·Ayla HumphreyPatrick F Bolton
Sep 25, 2007·Journal of Child Neurology·Evald SaemundsenVilhjalmur Rafnsson
Apr 30, 2008·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Sally J Rogers, Laurie A Vismara

❮ Previous
Next ❯

Citations

Sep 27, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hans HolthausenManfred Kudernatsch
Nov 3, 2015·Epilepsia·Harry T ChuganiEishi Asano
Nov 5, 2014·Annals of Neurology·Klaus WernerBrian G Neville
Oct 22, 2013·Neurologia Medico-chirurgica·Haruhiko KishimaToshiki Yoshimine
Jul 14, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Stephanie Garcia-TarodoGretchen K Von Allmen
Sep 4, 2018·Neurosurgical Focus·Taylor J AbelJames T Rutka
Oct 21, 2020·Nature Reviews. Neurology·Rima Nabbout, Mathieu Kuchenbuch
Oct 18, 2020·Annals of Neurology·Chih-Hong LeeJohn W Swann
Apr 13, 2021·Neurology. Clinical Practice·Karen LidzbaMartin Staudt
Jul 3, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Wafaa Al-ShehhiPuneet Jain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

© 2022 Meta ULC. All rights reserved