Long-term dienogest administration in patients with symptomatic adenomyosis

The Journal of Obstetrics and Gynaecology Research
Kazuaki NeriishiYutaka Osuga

Abstract

Adenomyosis is a common gynecological disorder that causes dysmenorrhea, hypermenorrhea and metrorrhagia. Previously, we reported that 24 weeks of dienogest treatment is highly effective for pain in symptomatic adenomyosis. Up to present, there is no report that describes treatment of adenomyosis with long-term dienogest administration for more than 2 years. In this retrospective cohort study, we investigated the course of long-term dienogest treatment in patients with symptomatic adenomyosis. This is a retrospective cohort study. Dienogest was continuously administered at a dose of 2 mg daily for patients with symptomatic adenomyosis. The outcome of long-term administration of dienogest was investigated, and the characteristics of patients were compared between discontinued cases and long-term administration cases. Two patients were excluded from this study because of transfer to another hospital or discontinuation due to infertility treatment. Twelve of 18 patients (66.7%) received dienogest until menopause or for a period of >80 months. Four cases (22.2%) discontinued dienogest treatment because of severe metrorrhagia. In the discontinued cases because of severe metrorrhagia, the pain score for dysmenorrhea and serum CA125 l...Continue Reading

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Citations

Oct 30, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Takashi MatsushimaToshiyuki Takeshita
Jan 18, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ahmed I HassaninMohammed K Ali
Oct 23, 2020·The Journal of Obstetrics and Gynaecology Research·Masashi TakamuraYutaka Osuga
Jan 6, 2021·The Journal of Obstetrics and Gynaecology Research·Tetsuya HirataYutaka Osuga
Feb 17, 2021·The Journal of Obstetrics and Gynaecology Research·Natsumi OnoEtsuko Miyagi
Mar 25, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Yosuke OnoShinichiro Wada
Jun 23, 2021·The Journal of Obstetrics and Gynaecology Research·Hiroshi Kobayashi, Shogo Imanaka
Aug 8, 2021·Journal of Clinical Medicine·Fady I ShararaGaby N Moawad
Aug 24, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yan PengPing Jin
Nov 10, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miaomiao JiGuoyun Wang
Jan 18, 2022·European Journal of Clinical Pharmacology·Kiran Kumar RathinamPriyadharshini A

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