Long-Term Dietary Intake of Chia Seed Is Associated with Increased Bone Mineral Content and Improved Hepatic and Intestinal Morphology in Sprague-Dawley Rats

Nutrients
Evelyn M Montes ChañiFabio J Pacheco

Abstract

Chia seeds (Salvia hispanica) provide an unusually high content of α-linolenic acid with several potential health benefits, but few studies have examined the long-term intake of n-3 fatty acid-rich plant foods such as chia. In this work, we investigated some of the effects of a diet containing 10% chia seeds versus a conventional isocaloric diet for 10 and 13 months on body measurements, musculoskeletal system, the liver, and the intestines of 20 male Sprague-Dawley rats assigned into two groups. The n-6/n-3 ratios for the control and chia diets were 7.46 and 1.07, respectively. For the first 10 months of the diet, the body parameters and weights were similar, but at 13 months, the bone mineral content (BMC) of the chia-fed rats was significantly higher than that of the controls whether in total or proximal areas of the left tibia. Also, significant positive correlations were found between the age of the chia group and the bone mineral density, BMC, weight of the musculoskeletal system, final body weight, and skin weight. Liver and intestinal examinations showed improved morphology associated with lower lipid deposit in hepatocytes and increased intestinal muscle layers and crypt size in the chia group. This study provides new ...Continue Reading

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Citations

Jul 31, 2020·Journal of the American College of Nutrition·Marcella Duarte Villas MishimaHércia Stampini Duarte Martino
Apr 27, 2019·Frontiers in Psychiatry·Ryan R KellyAmanda C LaRue
Aug 15, 2020·Frontiers in Veterinary Science·Marco Fantinati, Nathalie Priymenko
Mar 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Mariana GrancieriElvira Gonzalez de Mejia
Jun 3, 2021·Journal of Food Science·Nidia Del Carmen Quintal-BojórquezMaira Rubí Segura-Campos
Aug 12, 2021·Food & Function·Luciana de Abreu SilvaCamila Kümmel Duarte

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