Abstract
Nitric oxide (NO) is an important vascular signaling molecule that plays a role in vascular homeostasis. A reduction in NO bioavailability is thought to contribute to endothelial dysfunction, an early risk factor for both cardiovascular disease and type 2 diabetes. Dietary nitrate, through the nitrate-nitrite-NO pathway, may provide an alternate source of NO when the endogenous eNOS system is compromised. In addition to a role in the vascular system, NO may also play a role in the metabolic syndrome including obesity and glucose tolerance. To investigate the effect of long-term dietary nitrate supplementation on development of the metabolic syndrome in mice fed a high-fat diet. Following 1 week of acclimatisation, male (6-8 weeks) C57BL6 mice were randomly assigned to the following groups (10/group) for 12 weeks: (i) normal chow + NaCl (1 mmol/kg/day), (ii) normal chow + NaNO3 (1 mmol/kg/day), (iii) high-fat diet + NaCl (1 mmol/kg/day), and (iv) high-fat diet + NaNO3 (1 mmol/kg/day). Body weight and food consumption were monitored weekly. A subset of mice (5/group) underwent running wheel assessment. At the end of the treatment period, all mice underwent fasting glucose tolerance testing. Caecum contents, serum, and tissues (li...Continue Reading
References
Jun 26, 2002·The American Journal of Clinical Nutrition·Lydia A BazzanoPaul K Whelton
Dec 7, 2002·Behavior Genetics·Alexander A BachmanovMichael G Tordoff
May 26, 2004·Journal of Cell Science·William C Sessa
Jun 30, 2004·Free Radical Biology & Medicine·Jon O Lundberg, Mirco Govoni
Mar 5, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Jon O Lundberg, Eddie Weitzberg
Apr 6, 2006·Circulation·Ulrich Förstermann, Thomas Münzel
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nathan S BryanDavid J Lefer
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Apr 16, 2009·Diabetes·Zhanguo GaoJianping Ye
May 2, 2009·Disease Models & Mechanisms·Paul L Huang
Jun 30, 2010·Hypertension·Vikas KapilAmrita Ahluwalia
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mattias CarlströmJon O Lundberg
Dec 19, 2012·Free Radical Biology & Medicine·Xingbin YangKevin D Croft
Jan 11, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michaela M MitschkeAna Kilic
Feb 12, 2013·Free Radical Biology & Medicine·Mark GilchristNigel Benjamin
Nov 15, 2013·Antioxidants & Redox Signaling·Mattias CarlströmJon O Lundberg
Sep 25, 2014·Diabetes·Lee D RobertsJulian L Griffin
Apr 16, 2015·Nutrients·Mayu KasubuchiIkuo Kimura
Aug 1, 2015·Molecular Nutrition & Food Research·Ben McNallyLee D Roberts
Oct 10, 2015·Adipocyte·Lee D Roberts
Jun 4, 2016·Cell·Ara KohFredrik Bäckhed
Oct 23, 2016·Free Radical Biology & Medicine·J R BakkerN C Ward
Jan 21, 2017·Molecular Nutrition & Food Research·Lauren C BlekkenhorstCatherine P Bondonno
Feb 16, 2017·American Journal of Physiology. Endocrinology and Metabolism·Kazuo OhtakeJun Kobayashi
Apr 21, 2017·The American Journal of Clinical Nutrition·Karolin WeitkunatSusanne Klaus
Jun 10, 2017·Journal of Hypertension·Vance B MatthewsMarkus P Schlaich
Aug 11, 2017·Microbiome·Jose A Caparrós-MartínFergal O'Gara