PMID: 8020195Jul 1, 1994Paper

Long-term dietary vitamin E retards development of retrovirus-induced disregulation in cytokine production

Clinical Immunology and Immunopathology
Y WangR R Watson

Abstract

A 15-fold increase in dietary vitamin E (160 IU/liter) normalized hepatic and serum levels of vitamin E normally reduced by retrovirus infection. It also significantly retarded development of splenomegaly and hypergammaglobulinemia induced by retrovirus infection, while significantly restoring release of interleukin-2 (IL) and interferon-gamma by splenocytes which are suppressed by retrovirus infection. Retrovirus infection elevated production of IL-4 and IL-6 by splenocytes, but this elevation was inhibited by vitamin E. Increased levels of IL-6 and tumor necrosis factor-alpha produced by splenocytes during progression to murine AIDS were also inhibited by vitamin E. Vitamin E supplementation also helped restore retrovirus-suppressed splenocyte proliferation. These data indicate that vitamin E supplementation can help overcome retrovirus-induced reduction in tissue vitamin E, modulate cytokine release, and normalize immune dysfunctions during progression to murine AIDS.

Citations

Jan 1, 1996·Life Sciences·J E CheshierR R Watson
Dec 22, 1999·The Proceedings of the Nutrition Society·S N Han, S N Meydani
Dec 24, 2002·The British Journal of Nutrition·Philip C Calder, Samantha Kew
Mar 26, 2011·Journal of Medicinal Food·Yu-Rim LeeHyun-Sook Kim
Oct 26, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A Seaton, G Devereux
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