PMID: 6110912Mar 28, 1981Paper

Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party

Lancet

Abstract

A controlled trial of long term domiciliary oxygen therapy has been carried out in three centres in the U.K. The 87 patients, all under 70 years of age, who took part had chronic bronchitis or emphysema with irreversible airways obstruction, severe arterial hypoxaemia, carbon dioxide retention, and a history of congestive heart failure. The patients were randomised to oxygen therapy (treated) or no oxygen (controls). Oxygen was given by nasal prongs for at least 15 h daily, usually at 2 1/min. The two groups were well matched, both clinically and in terms of lung function and other laboratory findings. 19 of the 42 oxygen treated patients died in the five years of survival follow-up compared with 30 out of 45 controls: in the 66 men in this trial the survival advantage of oxygen did not emerge until 500 days had elapsed. Survival for the 12 female controls was surprisingly poor, 8 of them being dead at 3 years. Mortality was not easy to predict, though a summation of arterial carbon dioxide tension and red cell mass was helpful. Neither time spent in hospital because of exacerbations of respiratory failure nor work attendance were affected by oxygen therapy, but these patients were very ill at the start of the trial and many ha...Continue Reading

Citations

Jun 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·A J CrockettJ H Alpers
Jan 1, 1990·Lung·N J Douglas
Jan 19, 2005·Der Internist·H R Wirtz
Jan 6, 2007·Journal of Clinical Monitoring and Computing·Mario G IobbiRobert J Dickinson
Jan 19, 2013·Internal and Emergency Medicine·Alessia VerduriAlfredo Potena
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·E D Missov, De Marco T
Apr 13, 2013·Drugs & Aging·Timothy E AlbertsonAndrew L Chan
Jul 1, 1994·Disease-a-month : DM·R M Leach, D F Treacher
Aug 25, 1990·Lancet·T Solanki, E Neville
Jun 1, 1982·Controlled Clinical Trials·D L DeMetsB W Brown
Jun 1, 1996·General Pharmacology·J S Thompson, A H Morice
Jan 28, 2014·Archivos de bronconeumología·Francisco Ortega RuizJulia Tàrrega Camarasa
Feb 6, 2014·Archivos de bronconeumología·Francisco Ortega Ruiz
Jun 7, 2005·Primary Care·Robert D Ballard
Nov 28, 2013·Respiratory Medicine·Thomas J Ringbaek, Peter Lange
Sep 29, 2011·Revue des maladies respiratoires·B MelloniJ-F Muir
Oct 1, 2003·Gastroenterology·Peter SchenkChristian Müller
Dec 26, 2001·Transplantation Proceedings·B D Kahan
Sep 12, 2000·Lancet·T HigenbottamE Demoncheaux
Oct 3, 2003·Lancet·P M A Calverley, Paul Walker
Apr 25, 1981·Lancet·A A WoodcockD M Geddes
May 2, 1981·Lancet
May 23, 1981·Lancet·K V LowsonJ M Bishop
Dec 15, 1984·Lancet·R J WinterD M Geddes
Aug 23, 1985·Deutsche medizinische Wochenschrift
Jul 2, 1988·Lancet
Jun 8, 1996·Lancet·M DobsonN Khallaf
Jun 13, 2003·Clinics in Chest Medicine·Shahrokh Javaheri
Feb 2, 2010·Archivos de bronconeumología·María Asunción Nieto Barbero

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