Long-Term Durability of Carpentier-Edwards Magna Ease Valve: A One Billion Cycle In Vitro Study

The Annals of Thoracic Surgery
Vrishank RaghavAjit P Yoganathan

Abstract

Durability and hemodynamic performance are top considerations in selecting a valve for valve replacement surgery. This study was conducted in order to evaluate the long-term mechanical durability and hydrodynamic performance of the Carpentier-Edwards PERIMOUNT Magna Ease Bioprostheses, through 1 billion cycles (equivalent to 25 years). In vitro valve hydrodynamic performance, durability, and quantitative flow visualization were conducted in accordance with ISO 5840:2005 heart valve standard. The study valves were subjected to accelerated valve cycling to an equivalent of 25 years of wear. Hydrodynamic evaluations at intervals of 100 million cycles (2.5 years) were performed on the study valves. New uncycled Magna Ease valves were used as hydrodynamic controls in this study. A quantitative assessment of the fluid motion downstream of the control and study valves was performed using particle image velocimetry. The results between the test and control valves were compared to assess valve performance after an equivalent of 25 years of wear. All study valves met the ISO 5840 requirements for effective orifice area, 1.81 ± 0.06 cm(2) and 2.06 ± 0.17 cm(2), and regurgitant fraction, 1.11% ± 0.87% and 2.5% ± 2.34%, for the 21 mm and 23...Continue Reading

References

Oct 1, 1978·The Annals of Thoracic Surgery·R E ClarkR A Beauchamp
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·G ColantuoniC P Alfrey
Mar 30, 2002·Journal of Long-term Effects of Medical Implants·J Butany, R Leask
Sep 26, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·I Vesely
Jun 20, 2006·Annals of Biomedical Engineering·Hwa Liang LeoAjit P Yoganathan
Feb 10, 2012·Annals of Biomedical Engineering·Neelakantan SaikrishnanAjit P Yoganathan
Oct 5, 2013·Biomechanics and Modeling in Mechanobiology·Caitlin Martin, Wei Sun
Dec 10, 2014·Annals of Biomedical Engineering·Arash KheradvarSuncica Canic
Jul 19, 2015·The Annals of Thoracic Surgery·Thierry BourguignonMichel Aupart
Aug 1, 2015·Annals of Biomedical Engineering·Arash KheradvarBoyce Griffith

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Citations

Oct 19, 2016·The Journal of Thoracic and Cardiovascular Surgery·Fraser D RubensIan G Burwash
Jun 24, 2017·Interactive Cardiovascular and Thoracic Surgery·Sina StockMichael Scharfschwerdt
Jan 18, 2017·Circulation. Cardiovascular Imaging·Fabrizio DonatiPablo Lamata
Aug 5, 2020·Journal of Cardiothoracic Surgery·Taufiek K RajabYasir Abu-Omar
Sep 22, 2020·Journal of the American Heart Association·Alexander E KostyuninAnton G Kutikhin
Mar 17, 2018·BioMed Research International·Philipp MarxDaniel Wendt
Nov 30, 2019·Interactive Cardiovascular and Thoracic Surgery·Michiel D VriesendorpRobert J M Klautz
Feb 18, 2017·Biomedical Engineering Online·Francesca Maria SusinGiorgio Querzoli
Oct 3, 2019·JACC. Cardiovascular Interventions·Janarthanan SathananthanJohn G Webb
Jul 3, 2021·Journal of Cardiovascular Development and Disease·Igor VendraminUgolino Livi

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