Long-term effect of a chicken-based diet versus enalapril on albuminuria in type 2 diabetic patients with microalbuminuria

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Vanessa De MelloJorge L Gross

Abstract

In short-term studies, the replacement of red meat in the diet with chicken reduced the urinary albumin excretion rate (UAER) and improved lipid profile in type 2 diabetic patients with diabetic nephropathy. The present study sought to assess these effects over a long-term period, comparing the effects of a chicken-based diet (CD) versus enalapril on renal function and lipid profile in microalbuminuric type 2 diabetic patients. This was a randomized, open-label, controlled clinical trial with a follow-up of 1 year. The trial involved outpatients with type 2 diabetes attending a clinic of the Division of Endocrinology at a tertiary-care hospital. Twenty-eight microalbuminuric patients completed the study and were evaluated. Patients were randomized to an experimental diet (CD plus active placebo) or to treatment with enalapril (10 mg/day plus usual diet). The main outcome measure was UAER (according to immunoturbidimetry). Blood pressure, anthropometric indices, and compliance were also evaluated monthly. The glomerular filtration rate ((51)Cr-EDTA), and lipid, glycemic, and nutritional indices, were measured at baseline and quarterly. The UAER was reduced after CD (n = 13; from 62.8 [range, 38.4 to 125.1] to 49.1 [range, 6.2 to...Continue Reading

References

Jan 1, 1985·Kidney International·B J MaroniW E Mitch
Jan 3, 2001·Kidney International·L F FriedB L Kasiske
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Mar 26, 2003·Hypertension·Carl Erik MogensenUNKNOWN Preterax in Albuminuria Regression (PREMIER) Study Group
Sep 17, 2003·Current Diabetes Reports·Marion J Franz, Madelyn L Wheeler
Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Aug 23, 2005·Diabetes Research and Clinical Practice·Ahmet M SengulLevent Aydin
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Dec 7, 2011·The British Journal of Nutrition·Tatiana Pedroso de PaulaMirela Jobim de Azevedo
Aug 14, 2013·BMC Public Health·Roberta Aguiar SarmentoJussara Carnevale de Almeida
Oct 15, 2009·Diabetology & Metabolic Syndrome·Themis ZelmanovitzLuís H Canani
Jul 12, 2014·Atherosclerosis·Ana Luiza Teixeira dos SantosThemis Zelmanovitz
Jan 16, 2018·Nature Reviews. Nephrology·Peter StenvinkelRichard J Johnson
Aug 29, 2021·BMC Endocrine Disorders·Monireh AzizKhadijeh Mirzaei
Jan 27, 2010·Current Opinion in Lipidology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.