Jun 5, 2010

Long-term effect of carbodiimide on dentin matrix and resin-dentin bonds

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ana Karina Bedran-RussoCarina S Castellan


To characterize the interaction of 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide Hydrochloride (EDC) with dentin matrix and its effect on the resin-dentin bond. Changes to the stiffness of demineralized dentin fragments treated with EDC/N-hydroxysuccinimide (NHS) in different solutions were evaluated at different time points. The resistance against enzymatic degradation was indirectly evaluated by ultimate tensile strength (UTS) test of demineralized dentin treated or not with EDC/NHS and subjected to collagenase digestion. Short- and long-term evaluations of the strength of resin-dentin interfaces treated with EDC/NHS for 1 h were performed using microtensile bond strength (microTBS) test. All data (MPa) were individually analyzed using ANOVA and Tukey HSD tests (alpha = 0.05). The different exposure times significantly increased the stiffness of dentin (p < 0.0001, control-5.15 and EDC/NHS-29.50), while no differences were observed among the different solutions of EDC/NHS (p = 0.063). Collagenase challenge did not affect the UTS values of EDC/NHS group (6.08) (p > 0.05), while complete degradation was observed for the control group (p = 0.0008, control-20.84 and EDC/NHS-43.15). EDC/NHS treatment did not significantly increas...Continue Reading

  • References29
  • Citations31


  • References29
  • Citations31


Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Muscle Tensile Strength
Stress, Mechanical
Succinimide sodium salt
Resin Cements
Cure of Orthodontic Adhesives
Ethyldimethylaminopropyl Carbodiimide
Molar Tooth

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