Long-term effect of fundoplication on motility of the oesophagus and oesophagogastric junction

The British Journal of Surgery
R C H SchefferHein G Gooszen

Abstract

This study assessed the long-term effect of Nissen fundoplication on oesophageal and oesophagogastric junction (OGJ) motility. Symptoms were scored and oesophageal manometry performed in 34 consecutive patients with chronic gastro-oesophageal reflux disease, before, 3 months after and 2 years after surgery. Distal peristaltic amplitude increased from a median of 57 (95 per cent confidence interval (c.i.) 18 to 107) mmHg to 86 (95 per cent c.i. 54 to 208) mmHg (P < 0.001) at 3 months and 92 (45 to 210) mmHg (P < 0.001) at 2 years. In four patients the amplitude increased to more than 180 mmHg and three of these patients reported odynophagia. After surgery, a linear relationship was observed between the peristaltic amplitude and nadir OGJ relaxation pressure at 3 months (r(s) = 0.68, P < 0.001) and 2 years (r(s) = 0.64, P < 0.001). A significant correlation was also found between amplitude and both basal OGJ pressure and intrabolus pressure at 3 months (r(s) = 0.58, P < 0.001 and r(s) = 0.63, P < 0.001 respectively) and 2 years (r(s) = 0.71, P < 0.001 and r(s) = 0.49, P = 0.024). There was a relationship between peristaltic amplitude and the odynophagia score at 2 years (r(s) = 0.60, P = 0.017). Within 3 months of fundoplication ...Continue Reading

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Citations

Jan 27, 2009·Surgical Endoscopy·Ruxandra CiovicaMichael Gadenstätter
Dec 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Bas P L WijnhovenDavid I Watson
Apr 7, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Edgar J B FurnéeHein G Gooszen
Aug 13, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·John R SchererPeter James Kahrilas
Sep 14, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jennifer C MyersJohn Dent
Apr 29, 2009·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Filippo TosatoMarcello Bezzi
Jun 22, 2007·Anti-cancer Drugs·Laura G EstevezJesús García Mata
Oct 27, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Chike V Chukwumah, Jeffrey L Ponsky
Feb 6, 2009·Annals of Surgical Innovation and Research·Tarun SinghalShamsi El-Hasani
Jan 1, 2006·Women's Health·Jean-Marc Nabholtz, Joseph Gligorov
Dec 4, 2010·Best Practice & Research. Clinical Gastroenterology·Roberto Penagini, Ivana Bravi
Dec 25, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A J Bredenoord, A J P M Smout
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·F PizzaA Del Genio
Jun 12, 2014·United European Gastroenterology Journal·Taher I OmariJenifer C Myers
Oct 25, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G J BrinkC L Chen
Dec 10, 2016·World Journal of Gastrointestinal Surgery·Salvatore ToloneLudovico Docimo
Sep 19, 2018·Esophagus : Official Journal of the Japan Esophageal Society·Masato HoshinoKatsuhiko Yanaga
Nov 30, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J C MyersJ Dent

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