Long Term Effect of Intensive Lifestyle Intervention on Cerebral Blood Flow

Journal of the American Geriatrics Society
M A EspelandAction for Health in Diabetes Brain Magnetic Resonance Imaging Research Group

Abstract

To determine whether long-term behavioral intervention targeting weight loss through increased physical activity and reduced caloric intake would alter cerebral blood flow (CBF) in individuals with type 2 diabetes mellitus. Postrandomization assessment of CBF. Action for Health in Diabetes multicenter randomized controlled clinical trial. Individuals with type 2 diabetes mellitus who were overweight or obese and aged 45 to 76 (N = 310). A multidomain intensive lifestyle intervention (ILI) to induce weight loss and increase physical activity for 8 to 11 years or diabetes support and education (DSE), a control condition. Participants underwent cognitive assessment and standardized brain magnetic resonance imaging (MRI) (3.0 Tesla) to assess CBF an average of 10.4 years after randomization. Weight changes from baseline to time of MRI averaged -6.2% for ILI and -2.8% for DSE (P < .001), and increases in self-reported moderate or intense physical activity averaged 444.3 kcal/wk for ILI and 114.8 kcal/wk for DSE (P = .03). Overall mean CBF was 6% greater for ILI than DSE (P = .04), with the largest mean differences between ILI and DSE in the limbic region (3.39 mL/100 g per minute, 95% confidence interval (CI) = 0.07-6.70 mL/100 g pe...Continue Reading

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Citations

Aug 19, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rashid GhaznawiUNKNOWN UCC-SMART Study Group
Sep 30, 2020·Nutrition Reviews·Bo EkstrandRikard Landberg
May 31, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mark A EspelandUNKNOWN Action for Health in Diabetes (Look AHEAD) Research Group
Dec 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Priya BalasubramanianZoltan Ungvari
Jan 30, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carolyn S KaufmanEric D Vidoni
Feb 2, 2021·Frontiers in Physiology·Yu-Sok KimJohannes J van Lieshout
Mar 23, 2021·Journal of Diabetes and Its Complications·Felicia R SimpsonUNKNOWN Indices for Accelerated Aging in Obesity and Diabetes Ancillary Study of the Action for Health in Diabetes (Look AHEAD) Tria

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