Long-term effect of laser treatment for dry age-related macular degeneration on choroidal hemodynamics

American Journal of Ophthalmology
Mauricio FigueroaJuan E Grunwald

Abstract

To determine whether laser treatment applied according to the complications of age-related macular degeneration prevention trial (CAPT) has an effect on the choroidal circulation. Randomized controlled trial. This study included 30 CAPT patients with bilateral drusen. Laser Doppler flowmetry was used to measure relative choroidal blood flow (Ch(flow)) in the fovea. Measurements were obtained through dilated pupils in both eyes of each patient before photocoagulation was applied in one eye. Measurements were repeated at three months (30 patients) and 28 months (23 patients). Average Ch(flow) at baseline, three months, and 28 months was 7.2 +/- 2.1 (+/-1 SD), 7.3 +/- 2.5, and 6.8 +/- 2.7 arbitrary units (AU) in the control eyes and 6.6 +/- 1.6, 7.0 +/- 2.3, and 7.8 +/- 3.0 AU in the treated eyes. In comparison to control eyes, there was no significant change in Ch(flow) in the treated eyes at three months after treatment. At 28 months, however, there was a 5.6% drop in Ch(flow) in control eyes and an 18.2% increase in Ch(flow) in treated eyes from baseline. The average difference of 23.8% between the percentage changes in Ch(flow) observed in the control and treated eyes was statistically significant (paired two-tailed Student t ...Continue Reading

References

Jan 1, 1989·Ophthalmology·E FriedmanJ Seddon
Apr 1, 1995·Ophthalmology·E FriedmanE S Gragoudas
Mar 6, 1998·Archives of Ophthalmology·J E GrunwaldJ DuPont
Jan 30, 2002·The British Journal of Ophthalmology·Thomas A CiullaHanna J Garzozi
May 19, 2004·The British Journal of Ophthalmology·M FigueroaJ E Grunwald

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Citations

Sep 1, 2006·Photomedicine and Laser Surgery
Oct 19, 2010·Progress in Retinal and Eye Research·Einar StefánssonHaraldur Sigurdsson
Oct 24, 2015·The Cochrane Database of Systematic Reviews·Gianni VirgiliJennifer R Evans
Nov 28, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Giuseppe QuerquesFrancesco Bandello

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