Long-term effect of motor cortical repetitive transcranial magnetic stimulation [correction

Annals of Neurology
Takuya HayashiYoshikazu Ugawa

Abstract

Repetitive transcranial magnetic stimulation (rTMS) recently has been assessed as a noninvasive treatment modality for movement and psychiatric disorders, whereas the mechanism underlying the therapeutic effects is not fully understood. Studies in rodents showed lasting functional changes in some selected regions, such as limbic-associated structures, but unfocused brain stimulation did not clarify the regional effects. To address the topographical and temporal profiles of the effects on glucose metabolism in primate brain, we performed rTMS and repeated (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) before, during, and up to 16 days after rTMS in anesthetized cynomologous monkeys. We delivered a total of 2,000 pulses of 5 Hz-rTMS over the right precentral gyrus using a small-sized eight-figured coil that induced a localized electrical field. Voxel-based analysis in a standard space of the macaque brain showed statistically robust changes in FDG uptake: a decrease in the motor/premotor cortices and an increase in the limbic-associated areas involving the anterior/posterior cingulate, and orbitofrontal cortices. Interestingly, these uptake changes continued for at least 8 days and the magnitude of the lasting ef...Continue Reading

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Citations

Apr 21, 2007·Annual Review of Biomedical Engineering·Timothy WagnerAlvaro Pascual-Leone
Aug 24, 2007·Journal of Cognitive Neuroscience·Yasuo TeraoYoshikazu Ugawa
Sep 17, 2011·Rinshō shinkeigaku = Clinical neurology·Hideyuki Matsumoto, Yoshikazu Ugawa
Dec 28, 2011·International Review of Psychiatry·Ignacio ObesoAntonio P Strafella
Sep 2, 2009·Journal of the Neurological Sciences·Masashi HamadaUNKNOWN Effectiveness of rTMS on Parkinson's Disease Study Group, Japan
Apr 1, 2009·Brain Stimulation·Hartwig R SiebnerPaolo M Rossini
Jun 13, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Masashi HamadaUNKNOWN Effectiveness of rTMS on Parkinson's Disease Study Group, Japan
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Suk Yun KangMark Hallett
Oct 19, 2013·Expert Review of Neurotherapeutics·Sibylle C HerholzKarl Herholz
Jun 15, 2018·Frontiers in Human Neuroscience·Xiaoqin DuanWei Yang
Jan 24, 2021·NeuroImage·Takuya HayashiDavid C Van Essen

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