Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls

Journal of Virology
Josanne H VerhagenThijs Kuiken

Abstract

Infections of domestic and wild birds with low-pathogenic avian influenza viruses (LPAIVs) have been associated with protective immunity to subsequent infection. However, the degree and duration of immunity in wild birds from previous LPAIV infection, by the same or a different subtype, are poorly understood. Therefore, we inoculated H13N2 (A/black-headed gull/Netherlands/7/2009) and H16N3 (A/black-headed gull/Netherlands/26/2009) LPAIVs into black-headed gulls (Chroicocephalus ridibundus), their natural host species, and measured the long-term immune response and protection against one or two reinfections over a period of >1 year. This is the typical interval between LPAIV epizootics in wild birds. Reinfection with the same virus resulted in progressively less virus excretion, with complete abrogation of virus excretion after two infections for H13 but not H16. However, reinfection with the other virus affected neither the level nor duration of virus excretion. Virus excretion by immunologically naive birds did not differ in total levels of excreted H13 or H16 virus between first- and second-year birds, but the duration of H13 excretion was shorter for second-year birds. Furthermore, serum antibody levels did not correlate wit...Continue Reading

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Jan 1, 2014·Emerging Infectious Diseases·Josanne H VerhagenThijs Kuiken

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Citations

Jun 3, 2016·Integrative and Comparative Biology·Bethany J HoyeJan A van Gils
Sep 30, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Marjolein J PoenRon A M Fouchier
Dec 23, 2016·Proceedings. Biological Sciences·Sarah C HillOliver G Pybus
Apr 24, 2020·Journal of Virology·Josanne H VerhagenCamille Lebarbenchon
Oct 30, 2020·Journal of Virology·Nele VillabrunaMiranda de Graaf
Nov 17, 2021·Ecological Applications : a Publication of the Ecological Society of America·Katherine M InesonJonathan A Runstadler

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