Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria

American Journal of Hematology
Peter HillmenWendell F Rosse

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and life-threatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosis. We determined the incidence of renal dysfunction or damage, defined by stages of chronic kidney disease (CKD), in a large cohort of PNH patients and evaluated the safety and efficacy of the complement inhibitor eculizumab in altering its progression. Renal dysfunction or damage was observed in 65% of the study population at baseline with 21% of patients with later stage CKD or kidney failure (glomerular filtration rate [GFR] <or=60 ml/min/1.73 m(2); Stage 3, 4, or 5). Eculizumab treatment was safe and well-tolerated in patients with renal dysfunction or damage and resulted in the likelihood of improvement as defined as categorical reduction in CKD stage (P < 0.001) compared with baseline and to placebo (P = 0.04). Improvement in renal function was more commonly seen in patients with baseline CKD Stages 1-2 (67.1% improvement, P < 0.001) although improvement was also observed in patients with CKD Stages 3-4 (P = 0.05). Improvements occurred qui...Continue Reading

References

Jan 1, 1977·The American Journal of Medicine·A L RileyD A Roth
Jan 1, 1986·AJR. American Journal of Roentgenology·G P MulopulosJ W Clark
Apr 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M E MayM G Buse
Nov 9, 1995·The New England Journal of Medicine·P HillmenJ V Dacie
Sep 1, 1993·Journal of Computer Assisted Tomography·Y O TanakaT Abe
Feb 15, 2001·Regional Anesthesia and Pain Medicine·R M StoccheJ G Klamt
May 23, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F B Gabbai
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Feb 6, 2004·The New England Journal of Medicine·Peter HillmenRussell P Rother
Mar 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian DellesRoland E Schmieder
Oct 28, 2004·The British Journal of Radiology·J RimolaA Massuet
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Russell P RotherMark T Gladwin
Jul 30, 2005·Blood·Charles ParkerUNKNOWN International PNH Interest Group
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Sep 8, 2006·The New England Journal of Medicine·John S NguyenJohn A Flynn
Sep 23, 2006·The New England Journal of Medicine·Peter HillmenLucio Luzzatto
Sep 21, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aleksandra KuklaArjang Djamali
Dec 20, 2007·Journal of Hypertension·Markus P SchlaichRoland E Schmieder

❮ Previous
Next ❯

Citations

Jun 7, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Antonia BoutsLodewijk Spanjaard
Jul 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·José BallarínJuan Antonio Moreno
Jun 12, 2013·Nephron. Clinical Practice·S HussainJ Kazi
Dec 6, 2012·Experimental Hematology & Oncology·Andrés BrodskyMariano Volpacchio
Jun 9, 2012·Journal of the American Society of Nephrology : JASN·Leal C HerlitzVivette D D'Agati
Feb 22, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gillian M KeatingKate McKeage
Mar 29, 2014·Journal of Extracellular Vesicles·Bérangère DevaletChristian Chatelain
Jul 19, 2014·Experimental Hematology·Amy E DeZernRobert A Brodsky
Feb 21, 2016·Medicina clínica·Ana VillegasUNKNOWN Grupo de Trabajo de HPN de la Sociedad Española de Hematología y Hemoterapia
Sep 25, 2015·Journal of Receptor and Signal Transduction Research·Song Mao, Jianhua Zhang
Nov 13, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan SchmidtkoPascal Meier
Dec 16, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hubert Schrezenmeier, Britta Höchsmann
Apr 26, 2012·European Journal of Immunology·Peter F Zipfel, Christine Skerka
Apr 27, 2011·British Journal of Haematology·Lucio LuzzattoRosario Notaro
Sep 3, 2011·European Journal of Haematology·Alexander Röth, Ulrich Dührsen
Apr 16, 2011·Pediatric Transplantation·Magdalena RiedlTherese Jungraithmayr
Nov 15, 2011·Journal of Thrombosis and Haemostasis : JTH·S T A Van BijnenP Muus
Oct 11, 2012·European Journal of Haematology·Amy E DeZernRobert A Brodsky
Nov 15, 2013·Cytometry. Part B, Clinical Cytometry·Azra RazaAndrea Illingworth
Apr 30, 2014·Pediatric Blood & Cancer·Ulrike M ReissRussell E Ware
Dec 23, 2015·American Journal of Hematology·Michael LoschiRegis Peffault de Latour
Jun 5, 2015·Nephrology·See Cheng Yeo, Adrian Liew
Jul 3, 2013·Molecular Immunology·Edwin K S WongDavid Kavanagh
Mar 11, 2015·European Journal of Haematology·Bérangère DevaletChristian Chatelain
Feb 24, 2015·European Journal of Haematology·Jörg Schubert, Alexander Röth
Sep 9, 2015·Case Reports in Hematology·Pusem PatirFahri Sahin
Jun 5, 2015·Hematology/oncology Clinics of North America·Amy E DeZern, Robert A Brodsky
Sep 23, 2014·Blood·Robert A Brodsky
Dec 4, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Edwin K S Wong, David Kavanagh
Oct 26, 2016·International Journal of Hematology·Haruhiko NinomiyaYuzuru Kanakura
May 19, 2017·Nature Reviews. Disease Primers·Anita HillRobert A Brodsky
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joshua M Thurman
Jul 6, 2014·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Doug CoyleGerald A Evans

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