Abstract
Over the past two decades, vagus nerve stimulation (VNS) has become an accepted and viable treatment modality for intractable epilepsy both in children and adults. Earlier studies have demonstrated short-term seizure outcomes, usually for up to 5 years; so far, none have reported an extended outcome in children. We aimed to assess long term seizure outcome in children with intractable epilepsy for more than 5 years. We identified patients who had VNS implantation for treatment of intractable epilepsy from March 2000 to March 2015 at our Epilepsy Center and collected data including demographic, age at epilepsy onset and VNS implantation, duration of epilepsy, seizure type, number of antiepilepsy drugs (AEDs), and monthly seizure frequency before VNS implantation and at the last clinic visit. Phone surveys were conducted with patients without recent clinic follow-up. Fifty-six patients (aged 4-17 at the time of implant) are the subjects of the study. Seizure reduction of >50 % was achieved in 9.8 % (6th month), 24 % (2nd year), 46.4 % (3rd year), and 54 %(5th year), and overall 35 (62.5 %) of the 56 subjects had a greater than 50 % reduction in seizure frequency at the last follow-up. Eleven patients became seizure free. The resu...Continue Reading
References
May 13, 1998·Epilepsia·D LabarR Fraser
Jul 23, 1998·Neurology·A HandforthJ W Wheless
Jul 31, 1998·Pediatric Neurology·J V MurphyC L Tilton
May 5, 1999·Neurology·D LabarE Tecoma
Nov 24, 1999·Neurology·G L Morris, W M Mueller
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
Dec 6, 2001·Journal of Child Neurology·S L HelmersJ R Madsen
Sep 25, 2002·Neurology·Steven C Schachter
Nov 26, 2002·Clinical Neurology and Neurosurgery·Paolo TanganelliGiovanni Regesta
Apr 26, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M Vassilyadi, R H Strawsburg
Sep 24, 2005·Seizure : the Journal of the British Epilepsy Association·Tove HallböökIngmar Rosén
Jul 25, 2006·Seizure : the Journal of the British Epilepsy Association·Andreas V AlexopoulosWilliam E Bingaman
Jun 5, 2007·Seizure : the Journal of the British Epilepsy Association·J J ArdeschG Hageman
Jan 28, 2009·Epilepsia·Amre ShahwanA Simon Harvey
Oct 24, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ebru ArhanKemali Baykaner
Nov 6, 2009·Epilepsia·Patrick KwanJacqueline French
Dec 15, 2010·Epilepsy & Behavior : E&B·Robert E ElliottWerner K Doyle
May 3, 2011·Journal of Neurosurgery. Pediatrics·Robert E ElliottWerner K Doyle
Sep 9, 2011·The New England Journal of Medicine·Patrick KwanMartin J Brodie
Aug 11, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sylvia KlinkenbergAlbert P Aldenkamp
Sep 14, 2012·Neurology·Anne T BergFrancine M Testa
Nov 2, 2012·British Journal of Neurosurgery·Jared ChingDavid Sandeman
Feb 9, 2013·Seizure : the Journal of the British Epilepsy Association·Ravindra AryaTracy A Glauser
Jun 7, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Arthur CukiertMeire Argentoni-Baldochi
Aug 30, 2013·Neurology·George L MorrisCynthia Harden
Dec 19, 2013·Epilepsy Currents·George L MorrisCynthia Harden
Sep 19, 2014·Epilepsia·Iren OroszLieven Lagae
Oct 31, 2015·Epilepsy & Behavior : E&B·Vibhangini S WasadeMarianna Spanaki-Varelas
Citations
Feb 26, 2016·Acta neurologica Belgica·Mariangela PanebiancoAntonino Pavone
Oct 8, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Min-Jee KimTae-Sung Ko
Mar 29, 2018·Epilepsia Open·Yicong Lin, Yuping Wang
Nov 28, 2017·Journal of Child Neurology·Anup PatelSatyanarayana Gedela
Jan 9, 2020·The International Journal of Neuroscience·Jinbiao XiongQing Yu
Oct 5, 2017·Arquivos de neuro-psiquiatria·Tatiana Von Hertwig Fernandes de OliveiraSergio Leandro Stebel
May 1, 2020·Acta Neurologica Scandinavica·Jonathan J Halford, Jonathan C Edwards
May 16, 2019·Journal of Korean Neurosurgical Society·Jeyul Yang, Ji Hoon Phi
May 16, 2019·Journal of Korean Neurosurgical Society·Ki Hyeong LeeMichael Westerveld
Jan 16, 2019·Trials·Taoyun JiYuwu Jiang
Sep 18, 2020·Epilepsy & Behavior : E&B·Nallammai MuthiahTaylor J Abel
Aug 15, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Hongliang MaoHongwei Cheng
Aug 17, 2021·Neurology Research International·Mehdi AbbasiSeyed Amir Miratashi Yazdi
Sep 8, 2021·Frontiers in Neuroscience·Yulin SunGuang Yang
Sep 1, 2018·The Lancet Child & Adolescent Health·Orrin Devinsky
Oct 30, 2020·Seizure : the Journal of the British Epilepsy Association·Dènahin Hinnoutondji ToffaDang Khoa Nguyen