Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy

Endocrine
Elif A OralRebecca J Brown

Abstract

To evaluate the effects of metreleptin in patients with partial lipodystrophy (PL). Patients aged ≥ 6 months with PL, circulating leptin < 12.0 ng/mL, and diabetes mellitus, insulin resistance, or hypertriglyceridemia received metreleptin doses (once or twice daily) titrated to a mean of 0.124 mg/kg/day. Changes from baseline to month 12 in glycated hemoglobin (HbA1c) and fasting serum triglycerides (TGs; co-primary endpoints), fasting plasma glucose (FPG), and liver volume were evaluated. Additional assessments included the proportions of patients achieving target decreases in HbA1c or fasting TGs at month 12, long-term treatment effects, and treatment-emergent adverse events (TEAEs). Significant (p < 0.05) reductions in HbA1c (-0.6%), fasting TGs (-20.8%), FPG (-1.2 mmol/L), and liver volume (-13.4%) were observed in the overall PL population at month 12. In a subgroup of patients with baseline HbA1c ≥ 6.5% or TGs ≥ 5.65 mmol/L, significant (p < 0.05) reductions were seen in HbA1c (-0.9%), fasting TGs (-37.4%), FPG (-1.9 mmol/L), and liver volume (-12.4%). In this subgroup, 67.9% of patients had a ≥ 1% decrease in HbA1c or ≥ 30% decrease in fasting TGs, and 42.9% had a ≥ 2% decrease in HbA1c or ≥ 40% decrease in fasting TGs. ...Continue Reading

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Citations

May 12, 2019·The British Journal of Dermatology·N HaddadUNKNOWN PATIO group
Nov 9, 2019·Annual Review of Physiology·Francisco J A de Paula, Clifford J Rosen
May 6, 2020·Expert Review of Endocrinology & Metabolism·Maria C Foss-FreitasElif A Oral
Jul 18, 2019·The Journal of Clinical Endocrinology and Metabolism·Baris AkinciRebecca J Brown
May 23, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Christos BagiasStelios Tigas
Oct 15, 2020·Nature Communications·Pavlina ChrysafiChristos S Mantzoros
Feb 13, 2021·Journal of the American College of Cardiology·Nikolaos PerakakisChristos S Mantzoros
Mar 9, 2021·Journal of Neuromuscular Diseases·Antonio AtalaiaGisèle Bonne
Apr 6, 2021·Journal of the Endocrine Society·Keziah CookRebecca J Brown
Apr 16, 2021·The Journal of Experimental Medicine·Paola de CandiaGiuseppe Matarese
Apr 7, 2021·The Journal of Clinical Endocrinology and Metabolism·Keziah CookRebecca J Brown
Jul 31, 2021·Journal of Diabetes and Its Complications·Christopher D MorrisonDavid H McDougal
Jul 6, 2021·The Journal of Clinical Endocrinology and Metabolism·My-Le NguyenRebecca J Brown
Sep 8, 2021·Current Medical Research and Opinion·Kelly AdamskiRebecca J Brown
Oct 2, 2021·Clinical Diabetes and Endocrinology·O SaydamB Akinci
Oct 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Rasimcan MeralRebecca J Brown

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