Abstract
To evaluate the effects of metreleptin in patients with partial lipodystrophy (PL). Patients aged ≥ 6 months with PL, circulating leptin < 12.0 ng/mL, and diabetes mellitus, insulin resistance, or hypertriglyceridemia received metreleptin doses (once or twice daily) titrated to a mean of 0.124 mg/kg/day. Changes from baseline to month 12 in glycated hemoglobin (HbA1c) and fasting serum triglycerides (TGs; co-primary endpoints), fasting plasma glucose (FPG), and liver volume were evaluated. Additional assessments included the proportions of patients achieving target decreases in HbA1c or fasting TGs at month 12, long-term treatment effects, and treatment-emergent adverse events (TEAEs). Significant (p < 0.05) reductions in HbA1c (-0.6%), fasting TGs (-20.8%), FPG (-1.2 mmol/L), and liver volume (-13.4%) were observed in the overall PL population at month 12. In a subgroup of patients with baseline HbA1c ≥ 6.5% or TGs ≥ 5.65 mmol/L, significant (p < 0.05) reductions were seen in HbA1c (-0.9%), fasting TGs (-37.4%), FPG (-1.9 mmol/L), and liver volume (-12.4%). In this subgroup, 67.9% of patients had a ≥ 1% decrease in HbA1c or ≥ 30% decrease in fasting TGs, and 42.9% had a ≥ 2% decrease in HbA1c or ≥ 40% decrease in fasting TGs. ...Continue Reading
References
Jun 8, 2000·The Journal of Clinical Endocrinology and Metabolism·A Garg
Feb 22, 2002·The New England Journal of Medicine·Elif Arioglu OralAbhimanyu Garg
Mar 6, 2003·Reviews in Endocrine & Metabolic Disorders·Elif Arioglu Oral
Mar 19, 2004·The New England Journal of Medicine·Abhimanyu Garg
Sep 4, 2009·Diabetologia·A Y ChongP Gorden
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Abhimanyu Garg
Nov 10, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jean L ChanPhillip Gorden
Dec 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Vinaya SimhaAbhimanyu Garg
Sep 12, 2012·Hormone Research in Pædiatrics·F KamranR J Brown
Feb 26, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yehuda HandelsmanUNKNOWN American Association of Clinical Endocrinologists
Jun 14, 2014·The Journal of Clinical Endocrinology and Metabolism·Jalaja JosephRebecca J Brown
Jul 30, 2014·The Journal of Clinical Endocrinology and Metabolism·John D ChristensenRebecca J Brown
Mar 4, 2015·The Journal of Clinical Endocrinology and Metabolism·Talia Diker-CohenRebecca J Brown
Jul 4, 2015·Metabolism: Clinical and Experimental·Baris AkinciTevfik Demir
Aug 5, 2015·Nature Reviews. Endocrinology·Nivedita Patni, Abhimanyu Garg
Oct 16, 2015·Expert Review of Clinical Pharmacology·Cristina Adelia MeehanPhillip Gorden
Nov 19, 2015·Nutrients·Chiara SaponaroAmalia Gastaldelli
Nov 21, 2015·Diabetes, Obesity & Metabolism·C VatierC Vigouroux
Oct 28, 2016·Endocrine·Cristina Guillín-AmarelleDavid Araújo-Vilar
Sep 20, 2016·Journal of Diabetes & Metabolism·Nevin AjluniElif A Oral
Oct 7, 2016·The Journal of Clinical Endocrinology and Metabolism·Rebecca J BrownTohru Yorifuji
May 16, 2017·Journal of Clinical Lipidology·Ranganath MuniyappaRebecca J Brown
Jun 24, 2017·Metabolism: Clinical and Experimental·Baris AkinciElif Arioglu Oral
Oct 27, 2017·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Elaine ChiquettePraveen Dhankhar
Feb 16, 2018·Public Health Nutrition·Paula M HortaLuana C Dos Santos
Apr 13, 2018·Endocrine·Rebecca J BrownPhillip Gorden
Citations
May 12, 2019·The British Journal of Dermatology·N HaddadUNKNOWN PATIO group
Nov 9, 2019·Annual Review of Physiology·Francisco J A de Paula, Clifford J Rosen
Apr 9, 2020·Drugs·James E Frampton
May 6, 2020·Expert Review of Endocrinology & Metabolism·Maria C Foss-FreitasElif A Oral
Jun 12, 2020·AACE Clinical Case Reports·Natalia Xavier S de AndradeElif A Oral
Jul 18, 2019·The Journal of Clinical Endocrinology and Metabolism·Baris AkinciRebecca J Brown
Aug 6, 2020·Drug Design, Development and Therapy·Oluwayemisi Esan, Anthony S Wierzbicki
May 23, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Christos BagiasStelios Tigas
Oct 15, 2020·Nature Communications·Pavlina ChrysafiChristos S Mantzoros
Dec 15, 2020·Diabetes Research and Clinical Practice·Anjul SharmaStewart G Albert
Feb 13, 2021·Journal of the American College of Cardiology·Nikolaos PerakakisChristos S Mantzoros
Dec 29, 2020·Physiological Reviews·Koini LimDavid B Savage
Mar 9, 2021·Journal of Neuromuscular Diseases·Antonio AtalaiaGisèle Bonne
Apr 6, 2021·Journal of the Endocrine Society·Keziah CookRebecca J Brown
Apr 16, 2021·The Journal of Experimental Medicine·Paola de CandiaGiuseppe Matarese
Nov 25, 2020·Endocrine Journal·Masanori AdachiYumi Asakura
May 10, 2021·European Child & Adolescent Psychiatry·Jochen AntelJohannes Hebebrand
Apr 7, 2021·The Journal of Clinical Endocrinology and Metabolism·Keziah CookRebecca J Brown
Jun 26, 2021·Frontiers in Endocrinology·Vaia LambadiariFredrik Karpe
Jul 31, 2021·Journal of Diabetes and Its Complications·Christopher D MorrisonDavid H McDougal
Jul 6, 2021·The Journal of Clinical Endocrinology and Metabolism·My-Le NguyenRebecca J Brown
Aug 7, 2021·Autonomic Neuroscience : Basic & Clinical·Marina A DuVallDavid H McDougal
Sep 8, 2021·Current Medical Research and Opinion·Kelly AdamskiRebecca J Brown
Oct 2, 2021·Clinical Diabetes and Endocrinology·O SaydamB Akinci
Oct 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Rasimcan MeralRebecca J Brown
Dec 7, 2021·Lipids in Health and Disease·Maria C Foss-FreitasElif A Oral