Long-term effectiveness and safety of self-management of oral anticoagulants in real-world settings

BMC Cardiovascular Disorders
Bárbara Menéndez-JándulaLuis Larrad-Mur

Abstract

The patient self-management (PSM) is an effective approach for controlling the international normalized ratio, INR, within the therapeutic range. Nevertheless, most of the literature derives from randomized clinical trials, and no from routine clinical practice. The main objective of the present study was to evaluate long-term effectiveness and safety of PSM of oral anticoagulants (OACs) in real-world settings. This prospective cohort study involved 808 patients who were trained for PSM between July 2009 and March 2012, and followed-up for a maximum observational period of 5 years. The follow-up consisted of a visit to the physician every 6 months. All patients used the same type of portable coagulometer, able to store digitally up to 100 INR measurements. Effectiveness outcomes included the percentage of patients within the therapeutic range, the time within therapeutic range (TTR), and the evolution of the TTR over 365 days of follow-up. Long-term safety profile of PSM included the incidence of all-cause deaths and complications (thromboembolic or hemorrhagic) reported between July 2009 and June 2014, and the time to event. The median follow-up was 3.3 years. The percentage of patients within therapeutic INR target range was ...Continue Reading

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Citations

Nov 28, 2019·BMC Cardiovascular Disorders·Bárbara Menéndez-JándulaLuis Larrad-Mur

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