Long-term effectiveness and tolerability of topiramate in children with epilepsy under the age of 2 years: 4-year follow-up.

Journal of Korean Medical Science
Jung-Mi KimSung-Pa Park

Abstract

This is a long-term, open label, observational study aimed to broaden our clinical experiences in managing infants and toddlers with epilepsy. The long-term retention rate and side effects of topiramate (TPM) in them were evaluated and compared with carbamazepine (CBZ). A total of 146 children were involved in the study (TPM=41, CBZ=105). The retention rates at 24 , 36, and 48 months were 46.3%, 34.1%, 26.8% for TPM and 36.2%, 23.8%, 13.3% for CBZ, respectively. At 6 months after starting antiepileptic drugs (AED), the seizure freedom or clinical efficacy (seizure reduction rate more than 50 percent) were 73.2% for TPM and 62.9% for CBZ. The major side effects led to discontinuation included psychomotor slowing, poor oral intake from TPM and sleepiness and skin rash from CBZ. TPM was discontinued due to side effects in one case (2.4%) and lack of efficacy in five cases (12.2%), whereas CBZ was discontinued due to lack of efficacy (22.9%) and side effects (6.7%). As compared with CBZ, TPM showed the same long-term retention rate in children under the age of 2 yr, and no serious side effects. It is therefore concluded that TPM can be considered as a major AED for treating children with epilepsy under the age of 2 yr.

References

Apr 17, 1998·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·J E Markind
Mar 26, 1999·Seizure : the Journal of the British Epilepsy Association·E C MorelandK R Holden
Jun 17, 1999·Pediatric Neurology·W E RosenfeldR A Reife
Jan 21, 2000·Journal of Child Neurology·A SpaliceP Iannetti
Jun 14, 2000·Seizure : the Journal of the British Epilepsy Association·K MohamedL Rosenbloom
Feb 13, 2001·Seizure : the Journal of the British Epilepsy Association·M Nieto-BarreraL R del Portal
Feb 24, 2001·Journal of Child Neurology·B F Bourgeois
Feb 24, 2001·Journal of Child Neurology·J W Wheless
May 17, 2001·Paediatric Drugs·D Ormrod, K McClellan
Mar 29, 2002·Journal of Child Neurology·Martina Bebin
Mar 5, 2003·Acta Neurologica Scandinavica·M D PriviteraUNKNOWN EPMN 105 Study Group
Apr 16, 2003·Epilepsy Research·Yann MikaeloffCatherine Chiron
Oct 10, 2003·CNS Drugs·John Waugh, Karen L Goa
Apr 19, 2005·Journal of Child Neurology·Lubov BlumkinNathan Watemberg
Feb 3, 2007·Seizure : the Journal of the British Epilepsy Association·Steve ChungNicole Hank
Jun 21, 2007·Current Treatment Options in Neurology·Amy D Malphrus, Angus A Wilfong
Jul 11, 2007·Journal of Child Neurology·Rudolf Korinthenberg, Andreas Schreiner
Jul 28, 2007·Neuroscience and Behavioral Physiology·K V VoronkovaA S Petrukhin
Apr 3, 2008·Clinical Neuropharmacology·Li-Ping ZouUNKNOWN Topiramate Study Group

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Citations

May 11, 2011·Pediatric Neurology·Hannah C GlassMichael I Shevell
Jun 24, 2010·Early Human Development·Dorottya Kelen, Nicola J Robertson
Mar 19, 2014·Journal of Clinical Psychopharmacology·Matej Stuhec

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