Long-term effects of a 12-week exercise training program on clinical outcomes in idiopathic pulmonary fibrosis

Lung
Baruch VainshelboimMordechai Reuven Kramer

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, lung disease, with few therapeutic options. Data are limited with respect to the long-term effect of exercise training (ET) in IPF. This study sought to evaluate the long-term effects of a 12-week ET program on clinical outcomes in IPF patients. Thirty-four IPF patients were randomly allocated to ET or control groups. ET group participated in a 12-week supervised exercise program, while the control group continued with regular medical treatment alone. Exercise capacity, 30 s-chair-stand test for leg strength, dyspnea, and Saint George's Respiratory Questionnaire (SGRQ) for quality of life (QOL) were assessed at baseline and re-evaluated at 11 months from baseline. In addition, at 30-month time point from baseline, the impact of the 12-week intervention was analyzed with respect to survival and cardio-respiratory-related hospitalizations. Thirty-two patients completed the 12-week intervention and 28 patients (14 in each group) were re-evaluated. At 11-month follow-up, no significant differences between the groups and time effect were demonstrated for most outcomes. ET group showed preserved values at the baseline level while the control group showed a trend of deteri...Continue Reading

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Citations

Feb 13, 2016·Archives of Physical Medicine and Rehabilitation·Baruch VainshelboimJose Oliveira
Apr 28, 2016·Journal of Cardiopulmonary Rehabilitation and Prevention·Baruch VainshelboimMordechai Reuven Kramer
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