PMID: 16522993Mar 9, 2006Paper

Long-term effects of a losartan- compared with an atenolol-based treatment regimen on carotid artery plaque development in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy

The Journal of Clinical Hypertension
Eigil FossumS Julius

Abstract

In the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) study, there was a 25% risk reduction for stroke with angiotensin receptor blocker-based therapy (losartan) as compared with beta-blocker-based therapy (atenolol) despite comparable blood pressure reductions. This substudy examines treatment effects on the amount and density of atherosclerotic lesions in the common carotid arteries and the carotid bulb in 81 patients during 3 years of treatment. There were no statistically significant changes in the amount of carotid plaque in patients treated with losartan compared with an atenolol-based treatment program. A statistically nonsignificant increase in plaque density and index (average of plaque amount and density) was seen in the atenolol group compared with those treated with losartan. The small number of patients evaluated may have limited the power to detect a difference in outcome. The difference in carotid plaque index increase between the treatment groups during 3 years of treatment could not be statistically linked to specific treatments in the present substudy.

References

Aug 18, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·Y P SunW W Parmley
Mar 7, 2002·The American Journal of Cardiology·J David Spence
Aug 13, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Allan R BrasierMohsen S Eledrisi
Nov 9, 2002·Lancet·Majid EzzatiUNKNOWN Comparative Risk Assessment Collaborating Group

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Citations

May 8, 2007·The American Journal of Geriatric Cardiology·Donna S Hanes, Matthew R Weir
Jul 30, 2008·Blood Pressure·Talma Rosenthal, Naomi Nussinovitch
Jul 9, 2013·Indian Journal of Psychological Medicine·Victor Olufolahan Lasebikan, Olatunde Olayinka Ayinde
Jul 13, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yuhei ShigaKeijiro Saku

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