Long-term effects of a single exposure to immobilization on the hypothalamic-pituitary-adrenal axis: neurobiologic mechanisms

Annals of the New York Academy of Sciences
A ArmarioS Ons

Abstract

In apparent contrast to previous results from other labs, we have found that a single exposure to a severe stressor such as immobilization (IMO) caused a long-term desensitization of the hypothalamic-pituitary-adrenal (HPA) response to the homotypic stressor. Because such HPA desensitization was not found in response to heterotypic stressors, it seemed at first that we were describing a habituation process already observed after a single experience with the stressor. However, a more detailed analysis revealed two main properties incompatible with the interpretation of the results in terms of habituation: (1) The intensity of desensitization increases over the course of days to weeks with no additional exposures to the stressor, and (2) the degree of desensitization was greater with more severe stressors. The long-term effects were also observed after a single exposure to a high dose of a systemic stressor such as endotoxin but not after insulin-induced hypoglycemia, suggesting that not all severe systemic stressors can induce such long-term desensitization. Because systemic stressors are known to be processed in specific brain areas and because we have found changes in c-fos mRNA response to the homotypic stressor in some brain...Continue Reading

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Citations

Feb 10, 2012·Applied Psychophysiology and Biofeedback·Katja PetrowskiMartin Siepmann
Jun 14, 2012·Pharmacology, Biochemistry, and Behavior·Clara Ros-Simó, Olga Valverde
Jan 1, 2009·General and Comparative Endocrinology·H Bobby FokidisPierre Deviche
Aug 2, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·J CardasJ R Sanchez-Martín
Feb 8, 2008·Neurotoxicology and Teratology·Thitinart SithisarnSandra J Legan
Oct 1, 2009·The European Journal of Neuroscience·Rachel A KohmanAlexander W Kusnecov
Jan 16, 2007·European Journal of Pain : EJP·Yeong-Ray WenWei-Zen Sun
Jun 20, 2015·Nature Reviews. Neuroscience·Jaideep S BainsWataru Inoue
May 16, 2006·Hormones and Behavior·François S Guimont, Katherine E Wynne-Edwards
Dec 29, 2016·Stress : the International Journal on the Biology of Stress·Jereme G SpiersJohn D Lee
Apr 26, 2007·American Journal of Physiology. Endocrinology and Metabolism·Alena A ZalutskayaAbdul B Abou-Samra
May 22, 2007·Stress : the International Journal on the Biology of Stress·Esther L Sabban, Lidia I Serova
May 22, 2008·Endocrinology·David S Jessop
Aug 16, 2018·Cell and Tissue Research·Jatin NagpalSoojin Ryu

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