Long-term effects of acupuncture treatment on airway smooth muscle in a rat model of smoke-induced chronic obstructive pulmonary disease

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Jia LiJing Li

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases. It is a chronic inflammatory process characterised by airway obstruction and progressive lung inflammation, associated with difficulty breathing and insensitivity to corticosteroid therapy. Although there is some preliminary evidence to suggest a beneficial effect of acupuncture on COPD, its mechanism of action has not been investigated. Our aim was to examine the anti-inflammatory effects of acupuncture in a rat model of COPD induced by exposure to cigarette smoke (CS). Sixty Sprague-Dawley rats were exposed to the smoke of 15 cigarettes for 1 h/day, 6 days/week for 3 months to induce COPD and treated with acupuncture at BL13 (Feishu), BL23 (Shenshu) and Dingchuan (COPD+Acupuncture, n=15), sham acupuncture (COPD+Sham, n=15) or left untreated (n=15). Exposed rats were compared with controls not exposed to CS (control, n=15). Pulmonary function was measured, and tumour necrosis factor-α (TNF-α) and interleukin-8 (IL-8) levels were determined in bronchoalveolar lavage fluid by ELISA. Histone deacetylase 2 (HDAC2) protein and mRNA expression were examined in lung tissue and in bronchus. Acupuncture treatment appeared to protect pulmonary function...Continue Reading

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Citations

Nov 9, 2017·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yaqun LiangAngela Wei Hong Yang
Apr 20, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xin-Fang ZhangZi-Bing Liu
Mar 1, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xiaoyan JieJian-Hua Wang
Jun 4, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Ida NurwatiMuthmainah Muthmainah
Aug 8, 2020·Chinese Journal of Integrative Medicine·Hao HongBing-Mei Zhu
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Po-Chun HsiehChou-Chin Lan

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