Long-Term Effects of Acute Myeloid Leukemia Treatment on the Oral System in a Pediatric Patient

The Open Dentistry Journal
Saturnino Marco LupiSilvana Rizzo

Abstract

Acute Myeloid Leukemia (AML) in pediatric patients is a serious disease, although, for the subgroup of patients who receive proper treatment, a long-term survival rate above 50% is typical. The cycles of chemo- and radiotherapy used to treat AML can impair dental development. Herein, we describe the oral condition of a 25-year-old male patient treated for AML with chemo- and radiotherapy from 5 to 7 years of age; his AML has remained in remission for the past 18 years. He had lost only one permanent tooth, but the remaining teeth demonstrated serious deformations and radicular hypoplasia. Two teeth required immediate extraction and subsequent replacement by implant-supported crowns. We found that the decayed, missing, filled teeth (DMFT) index was not representative of the real oral condition. Here, we report the full case and provide a brief review of the literature. Antitumor treatment of pediatric leukemia can induce total impairment of dental development and function. These adverse effects may become clinically evident many years after the resolution of cancer, and can be significantly detrimental to the patient's quality of life.

References

Aug 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·R StaffordA Sonis
Dec 14, 2002·Leukemia Research·Eliana Maria MinicucciAdalberto José Crocci
Jan 11, 2003·Journal of Biomedical Materials Research. Part a·Davide ZaffeVirginio Quaglini
Jul 25, 2003·British Journal of Haematology·Leslie L Robison, Smita Bhatia
Jun 4, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas HerrmannDietmar Lehmann
Aug 19, 2005·Leukemia·A PessionUNKNOWN AML Strategy & Study Committee of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)
Mar 3, 2007·Pediatrics·Joseph D Dickerman
Dec 13, 2007·Cancer·Amy M Linabery, Julie A Ross
Feb 2, 2010·Hematology/oncology Clinics of North America·Jeffrey E RubnitzFranklin O Smith
Jun 3, 2010·Pediatrics in Review·John J Hutter
Jul 5, 2011·International Journal of Oral and Maxillofacial Surgery·S-W ChungI-H Cha
Mar 3, 2012·Blood·Gunnar JuliussonUNKNOWN Swedish Acute Leukemia Registry Group
Jul 14, 2012·Advances in Pediatrics·Kelly W MaloneyStephen P Hunger
Mar 26, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jason BrazeltonDeniz Peker
Jun 26, 2014·Clinics·Camila Merida CarrilloVicente Odone Filho
May 20, 2016·BioMed Research International·Daniele BollatiRuggero Rodriguez Y Baena
Jul 20, 2016·Indian Journal of Dentistry·Rekha RavikumarJulius Xavier Scott
Dec 3, 2016·The International Journal of Oral & Maxillofacial Implants·Ruggero Rodriguez y BaenaAlessandra Lucchese
Mar 25, 2017·Stem Cells International·Gabriele CeccarelliRuggero Rodriguez Y Baena

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Citations

Jul 31, 2019·Minerva stomatologica·Saturnino M LupiRuggero Rodriguez Y Baena
Jun 25, 2020·Cancers·Francisco Cammarata-ScalisiMichele Callea
Feb 14, 2019·International Journal of Molecular Sciences·Saturnino Marco LupiRuggero Rodriguez Y Baena
Aug 8, 2021·International Journal of Environmental Research and Public Health·Maja PtasiewiczRenata Chałas

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Methods Mentioned

BETA
hormone replacement therapy

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