Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons

Hippocampus
S BerrettaF M Benes

Abstract

Growing evidence indicates that the amygdala modulates hippocampal functions. To test the hypothesis that this modulation may involve long-lasting effects on interneuronal networks in the hippocampus, changes in the expression of neurochemical markers specific for different interneuronal subpopulations were assessed in adult rats 96 h following acute infusion of low doses of the GABAA receptor antagonist picrotoxin into the amygdala. The numerical density (Nd) of somata showing immunoreactivity (IR) for parvalbumin (PVB) was decreased in dentate gyrus (DG) and the CA4-2 region, while that of calretinin (CR)-IR was decreased in DG and CA2. The Nd of calbindin D28k (CB)-IR somata was decreased in CA3-2. The densities of axon terminals arising from PVB-IR and cholecystokinin (CCK)-IR basket neurons were also altered, with those of CCK-IR terminals increased across all sectors, while PVB-IR terminals were decreased only in the CA region. Increases in CCK-IR terminals were paralleled by increases of terminals with IR for the 65-kD isoform of glutamate decarboxylase (GAD65). Mixed-effects statistical models, adapted specifically for these analyses, indicated that perturbations of amygdalar inputs to the hippocampus significantly alte...Continue Reading

References

Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Apr 1, 1989·Journal of Neurophysiology·Y Chagnac-Amitai, B W Connors
Dec 15, 1989·Neuroscience Letters·M D SimpsonW J Skan
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 1, 1973·Archives of General Psychiatry·J R Stevens
Mar 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·J Chapman
Feb 15, 1980·The Journal of Comparative Neurology·D G Amaral, W M Cowan
May 13, 1982·Brain Research·K G BaimbridgeC O Parkes
Aug 1, 1995·Current Opinion in Neurobiology·G Buzsáki, J J Chrobak
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·P S ChardG D Ghadge
Jan 1, 1993·Schizophrenia Bulletin·B Bogerts
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·S K Sanders, A Shekhar
Jan 1, 1996·Brain Research. Molecular Brain Research·L X ZhangR M Post
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·G BuzsákiA Bragin
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·S E Arnold
Jun 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·W B BarrJ A Lieberman
Jan 28, 1998·Critical Reviews in Neurobiology·C A Tamminga
Mar 21, 1998·The American Journal of Psychiatry·P Sachdev
Jun 10, 1998·Neurobiology of Learning and Memory·M G Packard, L A Teather
Jul 1, 1998·Biological Psychiatry·F M BenesM S Todtenkopf
Jun 23, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·S IritaniH Kazamatsuri
Jul 23, 1999·Annals of the New York Academy of Sciences·J R Stevens

❮ Previous
Next ❯

Citations

Jun 15, 2006·Cellular and Molecular Neurobiology·Joseph T Coyle
Mar 9, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Behnaz Esmaeili, Anthony A Grace
Apr 5, 2007·Nature Protocols·Sabina Berretta, Francine M Benes
Jan 21, 2011·Journal of Psychiatry & Neuroscience : JPN·Noah L LazarDonald P Cain
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J LodgeAnthony A Grace
Dec 11, 2008·Journal of Visualized Experiments : JoVE·Miles G CunninghamSydney E Wong
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Barbara GisabellaFrancine M Benes
Jul 11, 2012·Developmental Neuroscience·Melanie P LeussisSusan L Andersen
Mar 10, 2015·Schizophrenia Research·Francine M Benes
Jun 18, 2011·Biological Psychiatry·Heather C Brenhouse, Susan L Andersen
Aug 24, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniel J Lodge, Anthony A Grace
Dec 26, 2009·Neuroscience and Biobehavioral Reviews·Ralf-Peter Behrendt
Oct 10, 2007·Journal of Neuroscience Methods·Miles Gregory CunninghamFrancine Mary Benes
Mar 10, 2009·The International Journal of Neuropsychopharmacology·Jennifer FrançoisAstrid Nehlig
Aug 6, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ralf-Peter Behrendt
Mar 24, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Y Du, A A Grace
Jan 21, 2006·Stress : the International Journal on the Biology of Stress·Sabina Berretta
Apr 12, 2013·Journal of Neurophysiology·G Mark FreemanErik D Herzog
Apr 16, 2013·Reviews in the Neurosciences·Ralf-Peter Behrendt
Nov 6, 2003·Statistical Methods in Medical Research·Nicholas Lange
Nov 15, 2020·Neuroscience and Biobehavioral Reviews·Anne AlbrechtGal Richter-Levin
Feb 25, 2018·Neurobiology of Learning and Memory·Gürsel Çalışkan, Oliver Stork

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.