Long-term effects of analgesics in a population of elderly nursing home residents with persistent nonmalignant pain

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Aida WonLewis A Lipsitz

Abstract

Little is known about the long-term effects of analgesics on functional status and well-being of nursing home residents with chronic pain. Using the Minimum Data Set, we performed a longitudinal study of nursing home residents (n = 10,372) with persistent pain. Using propensity score adjustment techniques, we compared the effect of different analgesics on changes in physical, cognitive, emotional, and social functioning, and examined rates of adverse events over a 6-month period. There was no change in the analgesic class for at least 6 months for 35.4% of residents, including 40% who received no analgesics during this time. Use of nonopioids was 37.9%, short-acting opioids was 18.9%, and long-acting opioids was 3.3%. We found improvement in functional status (adjusted hazard ratio = 1.85; 95% confidence interval [CI], 1.05-3.23) and social engagement (adjusted hazard ratio = 1.58; 95%, CI, 0.99-2.50) with long-acting opioids compared with short-acting opioids. There were no changes in cognitive status or mood status, or increased risk of depression with use of any analgesics, including opioids. There was a trend toward a lower risk of falls with use of any analgesics (adjusted odds ratio = 0.87; 95% CI, 0.70-1.06). Rates of ot...Continue Reading

References

Apr 1, 1990·Journal of the American Geriatrics Society·B A FerrellD Osterweil
Mar 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S L HartmaierC D Phillips
Jul 1, 1994·Journal of Gerontology·J N MorrisL A Lipsitz
May 1, 1993·Journal of the American Geriatrics Society·E A Sengstaken, S A King
Jun 13, 1998·Journal of the American Geriatrics Society·R CastenM H Kleban
Jun 13, 1998·Journal of the American Geriatrics Society·M P LawtonM H Kleban
Jan 27, 1999·Journal of the American Geriatrics Society·D M SmithR C McDonald
May 8, 2000·Journal of the American Geriatrics Society·G W CramerG D Thompson
Sep 1, 2000·The American Journal of Medicine·J H GurwitzD W Bates
May 10, 2001·JAMA : the Journal of the American Medical Association·J M TenoV Mor
May 1, 2001·The Gerontologist·B E FriesF L Bookstein
Jul 24, 2001·Archives of Internal Medicine·T S FieldD W Bates
May 2, 2002·Journal of the American Geriatrics Society·Suzanne G LeveilleJack M Guralnik
Nov 28, 2002·Scandinavian Journal of Medicine & Science in Sports·Y KonishiD Takeshita
Mar 27, 2003·Journal of the American Geriatrics Society·Rebecca S AllenLouis D Burgio
May 27, 2004·Journal of the American Geriatrics Society·Aida B WonLewis A Lipsitz

❮ Previous
Next ❯

Citations

Jul 20, 2010·Wiener medizinische Wochenschrift·Markus GoschUlrike Sommeregger
Oct 25, 2013·Wiener medizinische Wochenschrift·Katharina PilsGeorg Pinter
Feb 27, 2013·Age and Ageing·Aza AbdullaUNKNOWN British Geriatric Society
Dec 24, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Drake MorganChristy S Carter
Nov 5, 2008·The Gerontologist·Howard B DegenholtzDarren Liu
Dec 16, 2010·Health Care Management Review·Christina D Kang-YiNicholas G Castle
Oct 11, 2012·Journal of Pain Research·Jairo Moyano, Albert Figueras
Jan 5, 2011·Journal of Pain Research·Robert J Balch, Andrea Trescot
Jan 20, 2010·Annals of Internal Medicine·Kate M DunnMichael Von Korff
Oct 16, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·A Robles Bayón, F Gude Sampedro
Aug 22, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Beth D DarnallRoger Chou
Oct 16, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lara DhingraMaximilian Magun
Aug 13, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·M Cary ReidKevin L Zacharoff
Aug 26, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Patricia BruckenthalLori Reisner
Jan 9, 2013·Archives of Gerontology and Geriatrics·Silvia DeandreaEva Negri
Jul 31, 2012·Journal of Pain and Symptom Management·Kate L LapaneMyoung S Kim
Nov 8, 2011·The American Journal of Geriatric Pharmacotherapy·Emily P PeronJoseph T Hanlon
Jul 15, 2009·The Journal of Pain : Official Journal of the American Pain Society·Timothy W VictorErrol Gould
Jan 24, 2012·Journal of Gerontological Nursing·Debra BakerjianMary Ersek
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Jerome Schofferman, Daniel Mazanec
May 16, 2009·Research in Nursing & Health·Jennifer G DuncanByron J Gajewski
Oct 31, 2009·Pain Practice : the Official Journal of World Institute of Pain·Richard L Rauck
Feb 13, 2008·European Journal of Pain : EJP·Anneke A BoerlageCarin C D van der Rijt
Nov 19, 2011·Journal of the American Geriatrics Society·Sascha DublinLisa A Jackson
Feb 18, 2012·European Journal of Pain : EJP·M KölzschR Kreutz
Mar 18, 2015·International Wound Journal·Ulrika KällmanMargareta Lindgren
Mar 20, 2008·Archives of Physical Medicine and Rehabilitation·Rollin M Gallagher, Lisa J Rosenthal
Dec 29, 2012·The International Journal of Neuroscience·Laia Calvó-PerxasUNKNOWN Behalf Of The Registry Of Dementias Of Girona Study Group Redegi Study Group
Jul 15, 2015·Journal of the American Medical Directors Association·Kaisu H PitkalaJ Simon Bell
Jul 15, 2015·Zeitschrift für Gerontologie und Geriatrie·Markus Gosch
May 31, 2015·Aging Clinical and Experimental Research·César Gálvez-BarrónAlejandro Rodríguez-Molinero
Jun 18, 2010·Pain·Sally Elizabeth KendallGeana Paula Kurita
May 9, 2007·The Journal of Pain : Official Journal of the American Pain Society·Joseph ShegaDebra K Weiner
Nov 28, 2015·Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society·Donna BlissBeth Virnig
Nov 17, 2007·Archives of Gerontology and Geriatrics·Mauro ZanocchiMario Molaschi
Feb 25, 2011·The American Journal of Nursing·Anita M JablonskiMary Ersek
Jul 16, 2010·Wiener medizinische Wochenschrift·Georg PinterMichael Schirmer
Sep 25, 2017·Journal of the American Geriatrics Society·Jacob N HunnicuttKate L Lapane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.