Long-term effects of brief hypoxia due to cardiac arrest: Hippocampal reductions and memory deficits

Resuscitation
Vess StamenovaAsaf Gilboa

Abstract

To examine the effects of brief hypoxia (<7 min) due to cardiac arrest on the integrity of the brain and performance on memory and executive functions tasks. Patients after out-of-hospital cardiac arrest (CA) (n = 9), who were deemed neurologically intact on discharge, were compared to matched patients with myocardial infarction (MI) (n = 9). A battery of clinical and experimental memory and executive functions neuropsychological tests were administered and MRI scans for all patients were collected. Measures of subcortical and cortical volumes and cortical thickness were obtained using FreeSurfer. Manual segmentations of the hippocampus were also performed. APACHE-II scores were calculated based on metrics collected at admission to ICCU for all patients. Significant differences between the two groups were observed on several verbal memory tests. Both hippocampi were significantly reduced (p < 0.05) in the CA patients, relative to MI patients. Hippocampal subfields segmentation showed significantly reduced presubiculum volumes bilaterally. CA patients had on average 10% reduction in volumes bilaterally across hippocampal subfields. No cortical thickness differences survived correction. Significant correlations were observed in t...Continue Reading

Citations

Apr 14, 2019·Neurorehabilitation and Neural Repair·Marte C ØrboTorgil R Vangberg
Apr 26, 2019·Current Opinion in Critical Care·Liesbeth W BoyceCaroline M van Heugten
Apr 26, 2019·Current Opinion in Critical Care·Erik Blennow Nordström, Gisela Lilja
Aug 11, 2020·Journal of the American Heart Association·Marinos KosmopoulosDavid G Benditt
Mar 31, 2020·Chest·Daniel CombsSairam Parthasarathy
Mar 31, 2019·Journal of Affective Disorders·Alex PresciuttiSachin Agarwal

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