Long-term effects of calcium carbonate and 2.5 mEq/liter calcium dialysate on mineral metabolism

Kidney International
E SlatopolskyJ A Delmez

Abstract

Many investigators have shown that calcium carbonate (CaCO3) is an effective phosphate binder which also prevents the potential disabling effects of aluminum (Al) accumulation. However, hypercalcemia may develop in a substantial numbers of patients. Thus, to control serum phosphate (PO4) and prevent hypercalcemia, we performed studies in 21 patients on maintenance hemodialysis in which, in addition to the oral administration of CaCO3, the concentration of calcium (Ca) in the dialysate was reduced from 3.25 to 2.5 mEq/liter. The studies were divided in three periods: I. control, on Al-binders (one month); II. no Al-binders (one month); III. CaCO3 (seven months). Blood was obtained three times/week before dialysis for the first five months of the study and once a week for the remaining four months. During the control period, the mean serum calcium was 8.86 +/- 0.08 mg/dl. The value decreased to 8.65 +/- 0.07 mg/dl when phosphate binders containing aluminum were discontinued, and increased to 9.19 +/- 0.07 mg/dl (P less than 0.001 compared to period II) during oral supplementation with calcium carbonate. The mean serum phosphorus was 5.03 +/- 0.07 mg/dl during the control period, and increased to 7.29 +/- 0.91 mg/dl (P less than 0...Continue Reading

References

Jan 1, 1978·Nephron·R S GoldsmithW F Taylor
Apr 27, 1989·The New England Journal of Medicine·L R SchillerJ S Fordtran
Sep 1, 1989·The Journal of Clinical Investigation·A J BrownE Slatopolsky
Jan 1, 1989·The Journal of Clinical Investigation·M S SheikhJ S Fordtran
Oct 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R A ShermanR P Eisinger
Jul 17, 1986·The New England Journal of Medicine·E SlatopolskyJ A Delmez
Mar 1, 1986·Annals of Internal Medicine·J C MaynardN W Levin
Apr 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J A DelmezS L Teitelbaum
Mar 1, 1971·The Journal of Clinical Investigation·E SlatopolskyN S Bricker
Jul 19, 1984·The New England Journal of Medicine·H H MallucheM C Faugere
Jan 5, 1984·The New England Journal of Medicine·W L HenrichJ V Nixon
Jan 1, 1982·The Journal of Clinical Endocrinology and Metabolism·E M BrownS P Marynick
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A B HodsmanJ W Coburn
Jan 1, 1982·American Journal of Nephrology·A J FelsenfeldJ M Harrelson

Citations

Nov 4, 2005·Clinical Rheumatology·Dharmarajan RamaswamyAnita Soni
Jun 28, 2005·Clinical and Experimental Nephrology·Yoshinori TajiTakashi Kuwahara
Apr 30, 2013·Drugs·Fabio Malberti
Jan 12, 2002·Kidney International·John KyriazisIrene Grimani
May 20, 2003·Kidney International. Supplement·José G HervásSebastián Cerezo
Jul 18, 1991·The New England Journal of Medicine·L D Quarles, M K Drezner
Jul 20, 1995·The New England Journal of Medicine·K A Hruska, S L Teitelbaum
Dec 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guillaume JeanBernard Charra
Feb 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cristina KarohlRosa Maria Affonso Moysés
Feb 7, 2008·Seminars in Dialysis·Christopher W McIntyre
Jul 1, 1990·Postgraduate Medical Journal·K Farrington, P Sweny
May 5, 2012·Nephron. Clinical Practice·João M Frazão, Teresa Adragão
Aug 11, 2006·Paediatric Drugs·Helena Ziólkowska
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmen SánchezMulticentre Study Group Collaborators
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Akhtar AshfaqPravin C Singhal
Aug 16, 2006·Expert Opinion on Drug Safety·Jaume AlmirallMaria Pau Valenzuela Mujica
Sep 19, 2007·Expert Opinion on Emerging Drugs·Guido BellinghieriVincenzo Savica
Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·M BiaginiR Bargagna
Sep 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J KelberJ A Delmez
May 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M EmmettM B Cleveland
Aug 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S H HouJ E Bourdeau
Jan 1, 1996·Kidney International·J A DelmezE Slatopolsky
Mar 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T WeinreichE Ritz
Mar 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B A WaradyW E Harmon
Apr 15, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hiroshi NishiMasafumi Fukagawa
Oct 4, 2006·Hemodialysis International·Nigel ToussaintPeter G Kerr
Mar 27, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Visnja LezaicLjubica Djukanovic
Mar 12, 2004·Expert Opinion on Investigational Drugs·Alberto Falchetti
Jun 1, 1991·Clinical Pediatrics·J D HannaJ C Chan
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Joseph A Coladonato
Dec 4, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mahmoud Loghman-Adham
Jul 1, 2009·Expert Review of Endocrinology & Metabolism·Iren Szeki, Alastair Hutchison
Feb 24, 2001·Seminars in Dialysis·B F Palmer
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Leandro Junior LuccaSociedade Brasileira de Nefrologia

Related Concepts

Aluminum
Calcium
Chalk
Hemodialysis
Milk-Alkali Syndrome
Kidney Failure, Chronic
Orthophosphate
Dialysis Solutions

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