PMID: 1201145Nov 1, 1975Paper

Long-term effects of colestipol (U-26,597 A) on plasma lipids in familial type II hyperbetalipoproteinaemia

Atherosclerosis
R FellinG Crepaldi

Abstract

Results related to long term treatment with Colestipol (a new resin sequestering bile acids) in 23 subjects with familial hypercholesterolaemia, 12 with Type IIA, 8 with Type IIB and 3 homozygotes are reported. Patients were given 15 g/day active drug for a period of 12 months and a double dose (30 g/day) for a successive period of 4 months along with a low cholesterol, low saturated fat, polyunsaturated fat-rich diet. Mean cholesterol decrease was --42 +/- 18 mg/dl (P less than 0.05) after 12 months of 15 g/day Colestipol and --69 +/- 17 mg/dl (P less than 0.01) after the following 4 months of 30 g/day Colestipol. The difference between the two periods of treatment (15 g and 30 g/day was not statistically significant. A slight but not significant increase in triglyceride levels was observed. Serum uric acid showed a significant increase throughout the entire period of treatment. No malabsorption syndrome or signs of toxicity were seen. Most frequent side effects were constipation, nausea, and metheorism which, with the exception of 4 cases which were withdrawn from the study, were reported as being transitory and mild.

References

Jul 1, 1972·The Journal of Clinical Pharmacology and New Drugs·J R Ryan, A Jain
Nov 6, 1972·JAMA : the Journal of the American Medical Association·C J GlueckP Steiner
Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·D WATSON

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Citations

Mar 1, 1979·American Heart Journal·B L Martz
Jan 1, 1987·Medical Toxicology·L C Knodel, R L Talbert
Mar 1, 1986·The British Journal of Dermatology·H M DoeglasJ Schirm
Jun 15, 1983·Klinische Wochenschrift·O Leiss, K von Bergmann

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