Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension.

Journal of the American Geriatrics Society
Mark A EspelandWomen's Health Initiative Study of Cognitive Aging Study Group

Abstract

To determine whether small decrements in global cognitive function that conjugated equine estrogen (CEE) therapies have been shown to produce in older women persist after cessation and extend to specific cognitive domains. Randomized controlled clinical trial. Fourteen clinical centers of the Women's Health Initiative. Two thousand three hundred four women aged 65 to 80 free of probable dementia at enrollment. CEE 0.625 mg/d with or without medroxyprogesterone acetate (MPA, 10 mg/d) and matching placebos. Annual administrations of a battery of cognitive tests during and after the trial. Assignment to CEE-based therapies was associated with small mean relative decrements in global cognitive function and several domain-specific cognitive functions during the trial, which largely persisted through up to 4 years after the trial. The strongest statistical evidence was for global cognitive function (0.07-standard deviation decrements during (P=.007) and after (P=.01) the trial. For domain-specific scores, the mean decrements were slightly smaller, were less significant, and tended to be larger for CEE-alone therapy. CEE-based therapies, when initiated after the age of 65, produce a small broad-based decrement in cognitive function th...Continue Reading

Associated Clinical Trials

References

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Citations

Apr 13, 2013·Brain Research·Leslie VaughanUNKNOWN Women's Health Initiative Memory Study of Younger Women (WHIMS-Y) Study Group
Dec 16, 2011·The American Journal of Clinical Nutrition·May A BeydounAlan B Zonderman
Sep 17, 2013·Climacteric : the Journal of the International Menopause Society·Amos Pines
Feb 10, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph S GoveasMark A Espeland
Jul 23, 2011·American Journal of Public Health·Regina A ShihMark A Espeland
Aug 11, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mark A EspelandUNKNOWN WHIMSY and WHIMS-ECHO Study Groups
Oct 7, 2016·Drugs & Aging·Jelena Osmanovic-Barilar, Melita Salkovic-Petrisi
Dec 17, 2016·Journal of Alzheimer's Disease : JAD·Bushra ImtiazMiia Kivipelto
Jan 18, 2017·The Cochrane Database of Systematic Reviews·Jane MarjoribanksJasmine Lee
Jul 22, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nicole M ArmstrongSusan M Resnick
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Richard J SantenHugh S Taylor
Nov 18, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eleni ArmeniIrene Lambrinoudaki
Oct 7, 2017·Frontiers in Genetics·Khyobeni MozhuiKaren C Johnson
Oct 9, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Huan-Huan ZhouZhongxiao Wan

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