Aug 8, 1980

Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice

European Journal of Pharmacology
L R Steranka, E Sanders-Bush

Abstract

Continuous release of p-chloroamphetamine from subcutaneously implanted minipumps for 3 days decreased brain 5-hydroxytryptamine, but not norepinephrine or dopamine, when analyzed 2 weeks later. In contrast, 2 weeks after infusion of amphetamine, whole brain dopamine but not 5-hydroxytryptamine or norepinephrine, was decreased. Also, the high affinity uptake of [3H] dopamine was markedly and selectively reduced in striatal synaptosomes. Thus, neurotoxicity is apparently not unique to halogenated amphetamine derivatives, but is produced by amphetamine itself if administered continuously.

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Citations

Mentioned in this Paper

Amphetamine
Derivatives
Serotonin
Thyramine
Brain
Uptake
Norepinephrine, (+, -)-Isomer
Amphetamine Drug Class Measurement
Norepinephrine
Dopamine Measurement

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