Long-term effects of dextranomer endoscopic injections for treatment of urinary incontinence: an update of a prospective study of 31 patients

The Journal of Urology
H B LottmannG Läckgren

Abstract

A prospective study was initiated 7 years previously to assess the efficacy of endoscopic dextranomer based implants for pediatric structural incontinence. Preliminary results revealed that at 3 years 50% of the patients were either dry or significantly improved. We report long-term results in the same cohort of patients. A total of 33 children and adolescents 5 to 18 years old with severe incontinence due to sphincteric incompetence (exstrophy-epispadias complex in 13, neuropathic bladder in 16, bilateral ectopic ureter in 4) were enrolled. Of the patients 13 underwent 2 and 4 underwent 3 treatment sessions to achieve a definitive result. Mean injected volume was 3.9 ml (range 1.6 to 12) per session. At each evaluation patients were considered cured (dryness interval 4 hours), significantly improved (minimal incontinence requiring no more than 1 pad daily and no further treatment required) or treatment failures (no significant improvement). Videourodynamics were used to study the evolution of the bladder capacity, activity and compliance. A total of 31 patients were followed 3 to 7 years after the last injection. At 3 years after treatment 15 of 30 patients (50%) were dry or improved. One patient who had leakage after 3 years ...Continue Reading

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Citations

Jun 19, 2012·International Urogynecology Journal·Stefan MohrAnnette Kuhn
Sep 12, 2006·Nature Clinical Practice. Urology·Carlos R Estrada, Stuart B Bauer
Apr 2, 2011·Seminars in Pediatric Surgery·Ranjiv Mathews
Jul 16, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rohani B CenaKyoung-Oh Cho
Nov 4, 2008·Journal of Pediatric Urology·Rafal ChrzanTom P V M de Jong
Jun 4, 2008·Current Opinion in Urology·Sumit Dave, Joao L Pippi Salle
Dec 21, 2011·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·J M GuysC Borrionne

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