Long-term effects of dietary sodium intake on cytokines and neurohormonal activation in patients with recently compensated congestive heart failure

Journal of Cardiac Failure
Gaspare ParrinelloSalvatore Paterna

Abstract

A growing body of evidence suggests that the fluid accumulation plays a key role in the pathophysiology of heart failure (HF) and that the inflammatory and neurohormonal activation contribute strongly to the progression of this disorder. The study evaluated the long-term effects of 2 different sodium diets on cytokines neurohormones, body hydration and clinical outcome in compensated HF outpatients (New York Heart Association Class II). A total of 173 patients (105 males, mean age 72.5+/-7) recently hospitalized for worsening advanced HF and discharged in normal hydration and in clinical compensation were randomized in 2 groups (double blind). In Group 1, 86 patients received a moderate restriction in sodium (120mmol to 2.8g/day) plus oral furosemide (125 to 250mg bid); in Group 2, 87 patients: received a low-sodium diet (80mmol to 1.8g/day) plus oral furosemide (125 to 250mg bid). Both groups were followed for 12 months and the treatment was associated with a drink intake of 1000mL daily. Neurohormonal (brain natriuretic peptide, aldosterone, plasma rennin activity) and cytokines values (tumor necrosis factor-alpha, interleukin-6) were significantly reduced with a significant increase of the anti-inflammatory cytokine interleu...Continue Reading

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Citations

Nov 2, 2011·Internal and Emergency Medicine·Gaspare ParrinelloSalvatore Paterna
Jul 8, 2010·Current Heart Failure Reports·Mark Liszkowski, Anju Nohria
Jul 17, 2013·Current Heart Failure Reports·Terry A LennieDebra K Moser
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Mar 12, 2011·American Heart Journal·Gaspare ParrinelloPietro Di Pasquale
Jun 20, 2014·Heart Failure Reviews·Gaspare ParrinelloMihai Gheorghiade
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Dec 17, 2020·International Journal of Molecular Sciences·Yash Patel, Jacob Joseph
Apr 30, 2021·Heart Failure Reviews·Gaspare ParrinelloMihai Gheorghiade

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