Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats.

Journal of Developmental Origins of Health and Disease
Letícia Chavaglia CavaletR M Gomes

Abstract

Nutritional disorders during the perinatal period cause cardiometabolic dysfunction, which is observable in the early overfeeding (EO) experimental model. Therefore, severe caloric restriction has the potential of affecting homeostasis through the same epigenetic mechanisms, and its effects need elucidation. This work aims to determine the impact of food restriction (FR) during puberty in early overfed obese and non-obese animals in adult life. Three days after delivery (PN3), Wistar rats were separated into two groups: normal litter (NL; 9 pups) and small litter (SL; 3 pups). At PN30, some offspring were subjected to FR (50%) until PN60, or maintained with free access to standard chow. NL and SL animals submitted to food restriction (NLFR and SLFR groups) were kept in recovery with free access to standard chow from PN60 until PN120. Body weight and food intake were monitored throughout the experimental period. At PN120 cardiovascular parameters were analyzed and the animals were euthanized for sample collection. SLNF and SLFR offspring were overweight and had increased adiposity. Differences in blood pressure were observed only between obese and non-obese animals. Obese and FR animals have cardiac remodeling showing cardiomyoc...Continue Reading

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Citations

Sep 17, 2020·Journal of Developmental Origins of Health and Disease·Elena ZambranoAntonio Marcus Paes
Dec 17, 2020·International Journal of Molecular Sciences·Marie JosseCatherine Vergely

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