Long-term effects of elevated gastrin levels on calcitonin secretion

Journal of Endocrinological Investigation
M F ErdoganM Kulaksizoglu

Abstract

Gastrin and pentagastrin stimulate thyroid C cells and elevate serum calcitonin levels. Gastrin levels may be elevated when histamine-2 receptor blockers (H2RB) and/or proton pump inhibitors (PPI) are used, or in patients with pernicious anemia (PA). This study was designed to investigate the long-term effects of elevated gastrin levels on serum calcitonin levels. We conducted a pentagastrin stimulation test to evaluate C cell reserves in patients who had been using PPI and/or H2RB for an extended period, as well as in patients with PA. We compared the results with a healthy control group of similar age and sex. A total of 40 controls (26 women, 24 men) and 25 patients (15 women, 10 men) using H2RB and/or PPI, and 37 patients (24 women, 13 men) with PA were enrolled. The groups were similar in terms of mean age and sex distribution. Mean fasting gastrin levels, and mean baseline and pentagastrin-stimulated calcitonin levels were significantly higher in the H2RB+PPI and PA groups than in controls. No significant differences were observed between the H2RB+PPI and PA groups. There was no correlation between gastrin and calcitonin levels. However, mean calcitonin levels were significantly higher in subjects with high baseline gastr...Continue Reading

References

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Citations

Dec 9, 2010·Journal of Diabetes·Zachary Bloomgarden
Mar 18, 2010·The British Journal of Surgery·M CherenkoJ F Henry
Aug 21, 2013·Head & Neck·Pierpaolo TrimboliEnrico Papini
Aug 16, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Efstathios P PapadakisVasilios Karagiannis
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Jun 9, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Berit Ø ChristoffersenTrine Ryberg Clausen
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Jul 14, 2017·Clinical Diabetes and Endocrinology·Shrikant Tamhane, Hossein Gharib
Sep 18, 2015·Clinical Diabetes and Endocrinology·Shrikant Tamhane, Hossein Gharib

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