PMID: 7544845Oct 1, 1995Paper

Long-term effects of finasteride on invasive urodynamics and symptoms in the treatment of patients with bladder outflow obstruction due to benign prostatic hyperplasia

The Journal of Urology
T L Tammela, M Kontturi

Abstract

We assess the long-term effects of finasteride on bladder outlet obstruction and symptoms in the treatment of patients with benign prostatic hyperplasia. Of the original 36 patients assigned to treatment with 5 mg. finasteride daily (group 1) or placebo (group 2) for 6 months 27 completed an open extension study of 5 mg. finasteride for 4 more years. The possible relief of bladder outlet obstruction was monitored with repeated pressure-flow studies at baseline, 6 months and 4.5 years. The treatment resulted in a further slight decrease in detrusor pressure at maximum flow rate in group 1 and a significant decrease in group 2 during the 4-year period, whereas improvement in maximum flow rate did not achieve statistical significance. Concomitantly, there was a significant improvement in obstructive and irritative symptoms. Finasteride decreases bladder outlet obstruction moderately and only occasionally relieves it completely. However, the decrease in obstruction achieved in many patients is sufficient to improve the symptoms significantly. The beneficial effect is long-lasting.

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Citations

Nov 9, 2000·Neurourology and Urodynamics·G S SonkeJ J de La Rosette
Apr 21, 2005·Der Urologe. Ausg. A·R Berges, K Höfner
Jul 3, 2003·Urology·Barbara B M KortmannJean J M C H de la Rosette
Feb 23, 1999·The Urologic Clinics of North America·H L Holtgrewe
Aug 27, 2009·Therapeutics and Clinical Risk Management·Angela B Smith, Culley C Carson
Nov 23, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshihisa MatsukawaMomokazu Gotoh
Jan 15, 2000·Scandinavian Journal of Urology and Nephrology. Supplementum·P Ekman
Oct 12, 2010·The Cochrane Database of Systematic Reviews·James TacklindTimothy J Wilt
Jun 27, 2002·Current Urology Reports·G J Wise, E O Md
Mar 26, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshihisa MatsukawaKotoko Mitsui

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