Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring

Psychopharmacology
Raphael VartazarmianPatricia Boksa

Abstract

Assessment of the benefits versus risks associated with antidepressant use during pregnancy must include an analysis of possible drug effects on fetal development. Human studies indicate that prenatal fluoxetine exposure is associated with adverse neonatal outcomes. Animal modeling may provide useful information concerning possible long-term effects of prenatal fluoxetine exposure. Limitations in previous such studies using rat models may be overcome using a guinea pig model in which fluoxetine is delivered by osmotic pump throughout pregnancy. Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig. In subsequent experiments, guinea pigs received fluoxetine or vehicle via osmotic pump or no treatment throughout pregnancy. Outcome measures included: pregnancy characteristics, weight gain, and, in offspring as adults, pain threshold, acoustic startle responses and prepulse inhibition. There was no effect of treatment group on gestation length, number of live-births or still-births, maternal or offspring weight gain, and acoustic startle responses. In adult offspring, pain threshold was decreased by vehicle treatment during gestation. Prenatal fluoxe...Continue Reading

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Jul 22, 2011·The Journal of Pharmacology and Experimental Therapeutics·Catherine F CapelloMichael J Owens
Dec 7, 2013·Developmental Psychobiology·Liesbeth KnaepenElbert A Joosten
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Feb 26, 2014·Pharmacological Reviews·Chase H BourkeMichael J Owens
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