Long-term effects of footshock and social defeat on anxiety-like behaviours in rats: relationships to pre-stressor plasma corticosterone concentration

Stress : the International Journal on the Biology of Stress
Anne Marie Kinn RødRobert Murison

Abstract

We compared the consequences of two stressors, 'unnatural' inescapable footshocks (IFSs) and 'natural' social defeat (SD), on behaviours typically sensitive to stress [sucrose preference, open field (OF), elevated plus maze (EPM) and acoustic startle responses (ASRs)] and the association with pre-stressor plasma corticosterone concentration. After initial blood sampling, rats (n = 20 per group) were exposed to either 10 IFSs (1 mA intensity, 5 s duration each) or to 1 h SD (defeat by an aggressive resident male rat and further exposure but separated in a small cage) or to control procedures (handling). Rats were tested once for ASR (day 19), while the other behavioural tests were applied once weekly for 3 weeks. Both stress groups showed short-lasting lowered sucrose preference, and in the EPM they showed shorter total distance moved, shorter distance moved on open arms and less time on open arms compared to controls. In the OF test, IFS rats showed shorter total distance moved up to 2 weeks after stress. The SD group showed shorter total distance moved in the OF, which was only significant 2 weeks after stress. Low pre-stressor plasma corticosterone concentration was only associated with defecation (IFS rats) and latency to en...Continue Reading

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Citations

Nov 19, 2013·Neuroscience and Biobehavioral Reviews·Andrew P AllenGerard Clarke
Jan 30, 2014·Physiology & Behavior·Anne Marie Kinn RødJanne Grønli
Sep 29, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Julia Dias Villas-BoasMagda Alves de Medeiros
Jun 21, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·M P García-PardoM A Aguilar
May 2, 2014·Frontiers in Integrative Neuroscience·Marian L Logrip, Eric P Zorrilla
May 1, 2016·Psychoneuroendocrinology·Giacomo RonzoniGregorio Segovia
May 3, 2019·Psychopharmacology·M Carmen Blanco-GandiaMarta Rodríguez-Arias
Jan 10, 2018·Stress : the International Journal on the Biology of Stress·Diána BalázsfiDóra Zelena
Jul 7, 2019·Brain Sciences·Claudia JorgensenTyler Barton
Apr 10, 2019·Stress : the International Journal on the Biology of Stress·Marina Liliana González-Torres, Cristiano Valerio Dos Santos

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