Long-Term Effects of In Utero Antiretroviral Exposure: Systolic and Diastolic Function in HIV-Exposed Uninfected Youth

AIDS Research and Human Retroviruses
Vitor GuerraSteven D Colan

Abstract

The aim of this study was to evaluate the association of in utero exposure to highly active antiretroviral therapy (HAART) with left ventricular (LV) function and structure in HIV-exposed uninfected (HEU) children. A prospective, multisite cohort study in HEU children was conducted by the Pediatric HIV/AIDS Cohort Study (PHACS). Echocardiographic measures of LV systolic and diastolic function and cardiac structure were obtained from HEU subjects aged ≥6 years enrolled in the PHACS Surveillance Monitoring of ART Toxicities study. Echocardiographic Z-scores were calculated using normative data from an established reference cohort. We used adjusted linear regression models to compare Z-scores for echocardiographic measures from HEU children exposed in utero to HAART with those exposed to non-HAART, adjusting for demographic and maternal health characteristics. One hundred seventy-four HEU subjects with echocardiograms and maternal ARV information were included (mean age 10.9 years; 48% male, 56% black non-Hispanic). Among 156 HEU youth with any ARV exposure, we observed no differences in Z-scores for LV systolic function measures between youth exposed in utero to HAART (39%) and HAART-unexposed youth in either unadjusted or adjust...Continue Reading

References

Sep 21, 2002·Lancet·Steven E LipshultzUNKNOWN Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P(2)C(2) HIV) Study Group
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven E LipshultzSteven D Colan
Nov 15, 2007·The Journal of Antimicrobial Chemotherapy·Caroline Foster, Hermione Lyall
Mar 5, 2008·Arquivos brasileiros de cardiologia·Maria do Carmo Soares Alves CunhaLuciane Gaspar Guedes
May 21, 2008·Circulation·Bethany J FosterSteven D Colan
Oct 14, 2011·AIDS Patient Care and STDs·Raymond GrinerUNKNOWN Pediatric HIV/AIDS Cohort Study
May 21, 2013·Journal of the American College of Cardiology·Akshay S Desai

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Citations

May 29, 2016·Current HIV/AIDS Reports·Allison Ross EckardTerry C Dixon
Nov 26, 2019·European Journal of Pediatrics·Paula MartinsRaquel Seiça
Mar 30, 2018·AIDS·James D WilkinsonUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS)
Jun 3, 2021·Journal of Clinical Medicine·Audrey MonninJean-Pierre Molès
Jul 2, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Lukas CervenyFrantisek Staud

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Software Mentioned

SAS
SMARTT

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