Long-term effects of insulin-like growth factor (IGF)-I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency

Clinical Endocrinology
K F WilsonR Rosenfeld

Abstract

The aim of this investigation was to study the effect of relatively high dose IGF-I therapy given for several months, on serum levels of IGF-I, IGF-II and IGFBP-3, and on IGF-I pharmacokinetics in patients with growth hormone insensitivity due to GH receptor dysfunction. Two adolescent subjects from Ecuador were treated with recombinant IGF-I at a dosage of 120 micrograms/kg s.c. twice daily, in combination with a GnRH analogue for 8 months. Serum was sampled at baseline and at 3-8 months, for determination of IGF-I, IGF-II and IGFBP-3 by radioimmunoassay, and for evaluation of IGFBPs and IGFBP-3 protease activity by Western ligand blot and protease assay, respectively. Peak serum IGF-I levels ranged from 272 to 492 micrograms/l. Mean serum IGF-II levels were decreased concurrently with the increase in IGF-I. Serum IGFBP-3 levels failed to rise with prolonged IGF-I treatment. There was no apparent change in the half-life of IGF-I during the treatment period. IGF-I administration does not increase serum levels of IGFBP-3 or significantly alter IGF-I pharmacokinetics.

References

Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G LamsonR G Rosenfeld
Nov 15, 1990·The New England Journal of Medicine·A L RosenbloomP J Fielder
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J ZapfE R Froesch
Oct 12, 1989·The New England Journal of Medicine·S AmselemM Goossens
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J GodowskiW I Wood
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M E GeffnerC H Li
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W H Daughaday, B Trivedi
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·G BaumannR J Winter
Sep 1, 1986·The Journal of Pediatrics·R G RosenfeldR L Hintz

❮ Previous
Next ❯

Citations

Feb 10, 2009·Advances in Therapy·Arlan L Rosenbloom
Feb 22, 1996·Regulatory Peptides·B LeibushJ Gutiérrez
Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·A Spagnoli, R G Rosenfeld
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Klara SjögrenClaes Ohlsson
Jan 1, 1995·Progress in Growth Factor Research·R L Hintz
Sep 23, 2009·Clinical Endocrinology·Nilani JeyaratnaganthanJan Frystyk
Jan 20, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Julie P RichmondSteven A Zinn
Oct 31, 2012·The British Journal of Nutrition·Shibani GhoshRicardo Uauy
Oct 23, 1997·Endocrine Reviews·B Boersma, J M Wit
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·A L RosenbloomU Francke
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·M ShinadaL A Bach
Oct 24, 2009·The Journal of Clinical Endocrinology and Metabolism·Pouneh K FazeliAnne Klibanski
Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Gemma SesmiloAnne Klibanski
Feb 4, 2005·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Jun 18, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Arlan L Rosenbloom
Sep 1, 2012·Journal of Cachexia, Sarcopenia and Muscle·Vicky W W TsaiSamuel N Breit
Jan 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Jaime Guevara-AguirrePatricio Procel
Sep 1, 1995·Acta Paediatrica. Supplement·M O SavageR G Rosenfeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.