PMID: 9437227Jan 23, 1998Paper

Long-term effects of insulin-like growth factor (IGF)-I on serum IGF-I, IGF-binding protein-3 and acid labile subunit in Laron syndrome patients with normal growth hormone binding protein

European Journal of Endocrinology
H KanetyZ Laron

Abstract

A minority of patients with Laron syndrome have normal serum GH binding protein (GHBP), indicating that the defect is elsewhere than in the extracellular domain of the GH receptor. We have evaluated the effect of long-term IGF-I treatment on serum IGF-binding protein (IGFBP)-3 and the acid-labile subunit (ALS) in three sibling with Laron syndrome caused by a GH post-receptor defect and with normal GHBP. The children (a boy aged 3 years, a girl aged 4 years and a boy aged 10 years) were treated by daily s.c. injection of IGF-I in a dose of 150 micrograms/kg. IGFBP-3 was measured by RIA and Western ligand blotting, ALS by RIA. Based values of IGFBP-3 and ALS were low. During IGF-I treatment, the IGFBP-3 concentrations in the girl gradually increased, whereas in the boys there was a 60% decrease during the first week, followed by gradual increase towards baseline. The ALS concentrations followed a similar pattern. We conclude that IGF-I treatment induces and initial suppression and then an increase in the IGFBP-3 and ALS concentrations, confirming data from animal experiments that IGFBP-3 synthesis is not solely under GH control. The differences in responsiveness between the female and male siblings may reflect genetic differences...Continue Reading

Citations

Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·A Spagnoli, R G Rosenfeld
Nov 9, 2000·The Journal of Clinical Investigation·N A SimsP A Kelly
Mar 22, 2006·Expert Opinion on Investigational Drugs·Stephen F Kemp, Kathryn M Thrailkill
Sep 29, 2009·Journal of Veterinary Internal Medicine·R FinotelloF Minuto
Sep 27, 2005·Journal of the American Geriatrics Society·Takuya WatanabeTakashi Iguchi
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·M ShinadaL A Bach
Apr 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Antonio BianchiLaura De Marinis
Oct 30, 1998·The Proceedings of the Nutrition Society·W F BlumW Rascher
Jun 26, 2008·American Journal of Physiology. Endocrinology and Metabolism·Richard L BradleyEleftheria Maratos-Flier
Dec 8, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mo Kyung JungEun-Gyong Yoo
Jan 31, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zvi LaronNahum Vaisman

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