Long-term effects of lipase inhibition by orlistat on gastric emptying and orocecal transit time of a solid meal.

Journal of Gastroenterology
Piotr KocełakMałgorzata Szymszal

Abstract

We assessed the impact of a prolonged lipase inhibition upon gastric emptying (GE) and orocecal transit time (OCTT) of a 355-kcal low-fat solid meal. In double-blind manner, 40 obese women BMI > 30 kg/m2, randomly allocated into two equal groups, took orally t.i.d. 120 mg orlistat or placebo during 8 weeks of a weight-reducing management. At randomization and after 2 months, GE was measured simultaneously with OCTT by means of a 13C-octanoic acid and a hydrogen breath test, respectively. Lipolytic activity was evaluated with a 13C-mixed triglyceride breath test (13C-MTGBT). A profound lipase inhibition by orlistat was confirmed by a 79.5% +/- 16.9% reduction of the cumulative 6-h 13C recovery with 13CMTGBT. GE remained unchanged either in the orlistat (T1/2, 188 +/- 35 min start versus 198 +/- 36 min end) or the placebo (T1/2, 191 +/- 35 min start versus 180 +/- 39 min end) group. OCTT increased from 208 +/- 54 min to 271 +/- 64 min (P < 0.01) after orlistat treatment and did not change significantly (216 +/- 76 vs. 234 +/- 72 min) in the placebo group. No adverse effect on the GE and a moderate prolongation of the OCTT of a low-fat solid meal is to be expected under a prolonged treatment with orlistat at a typical dosage regimen.

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Citations

Jul 8, 2011·The British Journal of Nutrition·Małgorzata BożekMonika Piłka
Nov 1, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yi WangXinfu Guan
Jul 30, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Priya Sumithran, Joseph Proietto
Aug 21, 2013·Pharmacological Reports : PR·Magdalena Olszanecka-GlinianowiczJerzy Chudek
Dec 14, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kayode Ogungbenro, Leon Aarons
Jul 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia Delgado-ArosIrene Busciglio
Oct 24, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaotuan ZhaoJiande D Z Chen

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