PMID: 3772154Nov 1, 1986Paper

Long-term effects of local ionizing radiation treatment on Langerhans cells in mouse footpad epidermis

The Journal of Investigative Dermatology
S Cole

Abstract

Langerhans cells (LC) were studied with ADPase histochemistry in sheets of hind footpad epidermis from groups of CBA/H mice. Single, local 20-Gy doses of 250-kV x-rays were administered to the right hind feet of the mice when they were 3-4 months old, and LC were counted at intervals ranging from 2 to 24 months later. In unirradiated mice, aged 5-19 months, the mean density of LC in footpad was 1521-1617 cells/mm2. It dropped to 1137 +/- 86 cells/mm2 (mean +/- SE) in untreated 28-month-old mice. At times from 2-15 months after irradiation, normal mean densities of LC were present in footpad epidermis. On average, LC numbers were subsequently reduced to 1078 +/- 65/mm2 by 19 months after irradiation (71% of the cells in age-matched controls) and to 789 +/- 53/mm2 by 24 months (59% of the cells in age-matched controls). Loss of cells was focal. Chronic radiation-induced fibrosis and damage to circulatory function in skin may have contributed to impaired replacement of LC from bone marrow precursors. The possibility that late radiation-related depletion of the LC population permits development of skin tumors as a delayed consequence of exposure to ionizing radiation is discussed.

Citations

Apr 1, 1990·International Journal of Radiation Biology·J E Coggle, J P Williams
Jul 8, 2009·Radiation Research·Ryan J CummingsEdith M Lord
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Pei LiaoWilliam H McBride
Jun 30, 2004·Radiation Research·William H McBrideYu-Pei Liao
Jul 6, 2014·Radiation Research·Robert E RosesBrian J Czerniecki

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