Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus

Neuroscience
J-T LiT-M Si

Abstract

Blockade of the N-methyl-d-aspartate receptors (NMDARs) during the neonatal period has been reported to induce long-term behavioral and neurochemical alterations that are relevant to schizophrenia. In this study, we examined the effects of such treatment on recognition memory and hippocampal excitatory and inhibitory (E/I) balance in both adolescence and adulthood. After exposure to the NMDAR antagonist, MK-801, at postnatal days (PND) 5-14, male Sprague-Dawley rats were tested for object and object-in-context recognition memory during adolescence (PND 35) and adulthood (PND 63). The parvalbumin-positive (PV+) γ-aminobutyric acid (GABA)-ergic interneurons and presynaptic markers for excitatory and inhibitory neurons, vesicular glutamate transporter-1 (VGLUT1) and vesicular GABA transporter (VGAT) were examined in the hippocampus to reflect the E/I balance. We found that rats receiving MK-801 treatment showed deficits of recognition memory, reduction in PV+ cell counts and upregulation of the VGLUT1/VGAT ratio in both adolescence and adulthood. Notably, the changes of the VGLUT1/VGAT ratio at the two time points exhibited distinct mechanisms. These results parallel findings of hippocampal abnormalities in schizophrenia and lend ...Continue Reading

References

Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J DeFelipeE G Jones
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L E Eiden
Feb 15, 2003·Brain Research. Developmental Brain Research·Andrea MinelliFiorenzo Conti
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Madeline J Eacott, Gillian Norman
Apr 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·S M WojcikC Rosenmund
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathan R WilsonGuosong Liu
Jul 4, 2006·Biological Psychiatry·Martin LepageSamarthji Lal
Oct 4, 2006·Brain Research Reviews·Teresa Marie du Bois, Xu-Feng Huang
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cheng Z WangKenneth M Johnson
May 23, 2008·Biological Psychiatry·Charan RanganathJ Daniel Ragland
Aug 30, 2008·Learning & Memory·Israela BalderasFederico Bermudez-Rattoni
Feb 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Huai-Xing Wang, Wen-Jun Gao
Jul 23, 2009·Psychiatry Research·David LuckMartin Lepage
Sep 2, 2009·Biological & Pharmaceutical Bulletin·Akiko Nakatani-PawlakYukio Yoneda
Apr 11, 2012·Molecular Psychiatry·J L RapoportN Gogtay

❮ Previous
Next ❯

Citations

Sep 14, 2016·Behavioural Brain Research·Sharon S LanderInna Gaisler-Salomon
Jan 19, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Amir ShojaeiNafiseh Atapour
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Kübra Akillioglu, Mustafa Karadepe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.