Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Wenneke van WeeldenRebecca C Painter

Abstract

Antidiabetic drugs (OADs) are increasingly prescribed to treat hyperglycaemia during pregnancy in women with gestational diabetes mellitus (GDM) or polycystic ovary syndrome (PCOS), even though long-term effects on offspring are unknown. This systematic review summarises the evidence of follow-up studies of randomised controlled trials (RCTs) reporting on long-term effects of prenatal exposure to OADs on offspring. The MEDLINE, EMBASE and CENTRAL databases were searched from inception to April 2018 for the concepts antidiabetic agents and prenatal exposure (or pregnancy and offspring/child) in combination with an RCT search filter. RCTs evaluating post-neonatal health effects in offspring and comparing maternal treatment with an OAD with no treatment, placebo, an alternative OAD or insulin during pregnancy were eligible for inclusion. Two independent researchers selected, extracted and assessed the data. Meta-analyses were performed using a random effects model and the Cochrane Collaboration's risk of bias tool was used for quality assessment. Ten studies were included, with a maximal follow-up duration of 9 years, comprising 778 children of mothers with GDM or PCOS who were randomised to either metformin or insulin/placebo dur...Continue Reading

References

Mar 15, 1996·American Journal of Epidemiology·I Hertz-PicciottoJ J Beaumont
Aug 29, 2002·The American Journal of Clinical Nutrition·Shumei Sun GuoAlex F Roche
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
May 4, 2005·Fertility and Sterility·Eszter VankySven Magnus Carlsen
Jan 19, 2006·Therapeutic Drug Monitoring·Bruce CharlesWilliam Hague
Jan 21, 2006·The Journal of Sexual Medicine·Richard Hayes, Lorraine Dennerstein
Aug 2, 2006·Fertility and Sterility·Cameron GilbertGideon Koren
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
Mar 29, 2008·BMJ : British Medical Journal·UNKNOWN Guideline Development Group
May 9, 2008·The New England Journal of Medicine·Janet A RowanUNKNOWN MiG Trial Investigators
May 23, 2008·Archives of Disease in Childhood·Mary S FewtrellAlan Lucas
Jan 20, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Edward J Coetzee
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Oct 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Eszter VankySven Magnus Carlsen
Nov 19, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·H IjäsT Raudaskoski
May 4, 2011·European Journal of Clinical Pharmacology·Cláudia de Oliveira BaraldiRicardo Carvalho Cavalli
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Sep 1, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Torstein B RøEszter Vanky
Oct 17, 2012·Pediatrics·Sven M CarlsenEszter Vanky
May 28, 2014·Human Reproduction Update·Matteo CassinaMaurizio Clementi
Dec 3, 2014·Cell Metabolism·Marc ForetzBenoit Viollet
Jan 16, 2015·BMJ Open·Carolyn A ChiswickJane E Norman
Mar 3, 2015·Obstetrics and Gynecology·Rachelle A SchwartzGideon Koren
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Moshe HodHema Divakar
Nov 5, 2015·Journal of Developmental and Behavioral Pediatrics : JDBP·Kristiina TerttiLeena Haataja
Dec 24, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M SimmondsN Woolacott
Feb 10, 2016·The Review of Diabetic Studies : RDS·Kristiina TerttiTapani Rönnemaa
Feb 26, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Trecia A WouldesJanet A Rowan
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Oded Langer
Jul 21, 2016·BMC Pregnancy and Childbirth·Denice S FeigUNKNOWN MiTy Collaborative Group
Nov 8, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Brianne E BimsonLois E Brustman
Jan 26, 2017·The Cochrane Database of Systematic Reviews·Julie BrownCaroline A Crowther
Mar 1, 2018·The Journal of Clinical Endocrinology and Metabolism·Liv Guro Engen HanemEszter Vanky
Oct 1, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Moshe HodHema Divakar

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Citations

Mar 21, 2019·Medical Sciences : Open Access Journal·Roger Hart
Jul 7, 2020·Frontiers in Pharmacology·Gonzalo JorqueraGonzalo Cruz
Feb 2, 2021·Endocrinology and Metabolism Clinics of North America·Amy M Valent, Linda A Barbour
Nov 18, 2020·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Victoria L RudlandLeonie Callaway
Apr 4, 2021·International Journal of Molecular Sciences·Ahmad J H Albaghdadi, Frederick W K Kan
Dec 11, 2020·Human Reproduction Update·Stefano PalombaLinda C Giudice
Sep 4, 2021·World Journal of Pediatrics : WJP·Ming-Zhi ZhangXu Wang
Sep 9, 2021·Current Diabetes Reports·Jamie L BenhamJennifer M Yamamoto

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