Long-term effects of pancreaticoduodenectomy on glucose metabolism

ANZ Journal of Surgery
Dong-Do YouWoo-Seok Kim

Abstract

To analyse the association between pancreatogenic diabetes and the volume of the remnant pancreas after pancreaticoduodenectomy and to identify clinicopathologic factors correlated with pancreatogenic diabetes. Among the patients who underwent pancreaticoduodenenctomy from 2003 to 2004, 55 patients who survived by 2009 and were able to measure the volume of the pancreas pre- and post-operatively by CT volumetry were included in this study. Twelve patients had diabetes before surgery. Median follow-up duration was 55.2 and 67.3 months for CT volumetry, pancreatogenic diabetes, respectively. Among 43 patients without preoperative diabetes, nine patients (21%) developed newly diabetes after surgery. Among 12 patients with diabetes, 10 patients had worsened glucose control. The immediate post-operative Vol% was 46.5% and the last Vol% was 31.5% (P < 0.001). Preoperative diabetes, malignant pathology, absence of post-operative pancreatic fistula, chemotherapy and radiotherapy were correlated with a lower Vol%. Atrophic changes were observed in 29 patients and hypertrophic changes in 13 patients. Comparative analysis according to the change in the Vol% revealed no differences in the clinicopathological factors associated with new-ons...Continue Reading

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Citations

Jul 9, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Keiichiro HirataKosei Hirakawa
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Jan 24, 2021·The Journal of Clinical Endocrinology and Metabolism·Fumimaru NiwanoHiroshi Ikegami
Feb 2, 2021·The American Surgeon·Tatsuya YamazakiMasahiko Murakami
Aug 3, 2021·Annals of Gastroenterological Surgery·Daisaku YamadaMasato Sakon

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