Long-term effects of placental growth on overweight and body composition.

International Journal of Pediatrics
J G ErikssonDavid J P Barker

Abstract

Obesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine whether placental size determines overweight and body composition, we studied 2003 subjects in adult life. Associations between placental surface area and indices of overweight were restricted to people who carried the Pro12Pro genotype of the PPARγ2 gene. For every 1 SD increase in placental surface area, the odds ratio for overweight was 1.37 (95% CI 1.10 to 1.71; P = 0.005). Expansion of the placental surface in compensation for fetal undernutrition increases the risk of overweight and a higher body fat percentage in people carrying the Pro12Pro genotype. We suggest that similar underlying multifactorial mechanisms affect the development of obesity in general.

References

Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Oct 28, 1999·The American Journal of Clinical Nutrition·A C RavelliO P Bleker
Feb 15, 2001·International Journal of Epidemiology·J E Harding
Apr 20, 2001·BMJ : British Medical Journal·J G ErikssonD J Barker
Jun 24, 2004·The American Journal of Clinical Nutrition·Avan Aihie SayerDavid I Phillips
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Oct 28, 2005·The New England Journal of Medicine·David J P BarkerJohan G Eriksson
Mar 16, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H YlihärsiläJ G Eriksson
Sep 19, 2007·American Journal of Epidemiology·Anu-Katriina PesonenJohan G Eriksson
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Gabriel PascualAndrea L Hevener
May 9, 2008·The New England Journal of Medicine·UNKNOWN HAPO Study Cooperative Research GroupDavid A Sacks
Jun 4, 2008·Annual Review of Biochemistry·Peter Tontonoz, Bruce M Spiegelman
Feb 12, 2009·Seminars in Fetal & Neonatal Medicine·Umberto Simeoni, David J Barker
Oct 31, 2009·The International Journal of Developmental Biology·Eero KajantieDavid J P Barker
Oct 31, 2009·The International Journal of Developmental Biology·David J P BarkerJohan G Eriksson
Mar 24, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Johan G ErikssonDavid J P Barker
Mar 24, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·David J P BarkerJohan G Eriksson
Sep 3, 2010·Endocrinology·Karim NadraBéatrice Desvergne
Jun 28, 2011·Journal of Reproductive Immunology·Thierry FournierDanièle Evain-Brion
Feb 1, 2008·Journal of Chemical Theory and Computation·Julian Tirado-Rives, William L Jorgensen

❮ Previous
Next ❯

Citations

Aug 7, 2013·Placenta·D J P Barker, K L Thornburg
Sep 9, 2016·Physiological Reviews·Graham J BurtonKent L Thornburg
Nov 13, 2019·Reproductive Toxicology·Barbara A CohnMary Beth Terry

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved